Improved loss-of-function CRISPR-Cas9 genome editing in human cells concomitant with inhibition of TGF-β signaling

Strategies to modulate cellular DNA repair pathways hold immense potential to enhance the efficiency of CRISPR-Cas9 genome editing platform. In the absence of a repair template, CRISPR-Cas9-induced DNA double-strand breaks are repaired by the endogenous cellular DNA repair pathways to generate loss-...

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Detalles Bibliográficos
Autores principales: Mishra, Tarun, Bhardwaj, Vipin, Ahuja, Neha, Gadgil, Pallavi, Ramdas, Pavitra, Shukla, Sanjeev, Chande, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961078/
https://www.ncbi.nlm.nih.gov/pubmed/35402072
http://dx.doi.org/10.1016/j.omtn.2022.03.003

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