The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway

A facile CuBr(2) induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds...

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Detalles Bibliográficos
Autores principales: Pan, You-lu, Gong, Xiao-meng, Hao, Rong-rong, Zeng, Shen-xin, Shen, Zheng-rong, Huang, Wen-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961271/
https://www.ncbi.nlm.nih.gov/pubmed/35424925
http://dx.doi.org/10.1039/d1ra06981k
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author Pan, You-lu
Gong, Xiao-meng
Hao, Rong-rong
Zeng, Shen-xin
Shen, Zheng-rong
Huang, Wen-hai
author_facet Pan, You-lu
Gong, Xiao-meng
Hao, Rong-rong
Zeng, Shen-xin
Shen, Zheng-rong
Huang, Wen-hai
author_sort Pan, You-lu
collection PubMed
description A facile CuBr(2) induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds exhibit bioactivity against cancer cell lines. This protocol shows advantages of low-cost, base-free, simple operation, and broad functional group tolerance.
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spelling pubmed-89612712022-04-13 The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway Pan, You-lu Gong, Xiao-meng Hao, Rong-rong Zeng, Shen-xin Shen, Zheng-rong Huang, Wen-hai RSC Adv Chemistry A facile CuBr(2) induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds exhibit bioactivity against cancer cell lines. This protocol shows advantages of low-cost, base-free, simple operation, and broad functional group tolerance. The Royal Society of Chemistry 2022-03-29 /pmc/articles/PMC8961271/ /pubmed/35424925 http://dx.doi.org/10.1039/d1ra06981k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Pan, You-lu
Gong, Xiao-meng
Hao, Rong-rong
Zeng, Shen-xin
Shen, Zheng-rong
Huang, Wen-hai
The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
title The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
title_full The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
title_fullStr The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
title_full_unstemmed The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
title_short The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway
title_sort synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5h)-ones derivatives via a free radical cascade pathway
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961271/
https://www.ncbi.nlm.nih.gov/pubmed/35424925
http://dx.doi.org/10.1039/d1ra06981k
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