The synthesis of anticancer sulfonated indolo[2,1-a]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-ones derivatives via a free radical cascade pathway

A facile CuBr(2) induced radical relay addition/cyclization of activated alkenes with substituted-thiosulfonates has been achieved, leading to a broad range of sulfonated indolo[2,1-a]isoquinolines and benzimidazo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields. In particular, some compounds...

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Detalles Bibliográficos
Autores principales: Pan, You-lu, Gong, Xiao-meng, Hao, Rong-rong, Zeng, Shen-xin, Shen, Zheng-rong, Huang, Wen-hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961271/
https://www.ncbi.nlm.nih.gov/pubmed/35424925
http://dx.doi.org/10.1039/d1ra06981k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961271/
https://www.ncbi.nlm.nih.gov/pubmed/35424925
http://dx.doi.org/10.1039/d1ra06981k

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