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Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase
On an organismal level, metabolism needs to react in a well-orchestrated manner to metabolic challenges such as nutrient uptake. Key metabolic hubs in human blood are pyruvate and lactate, both of which are constantly interconverted by very fast exchange fluxes. The quantitative contribution of diff...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961325/ https://www.ncbi.nlm.nih.gov/pubmed/35360693 http://dx.doi.org/10.3389/fnut.2022.785999 |
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author | Schlicker, Lisa Zhao, Gang Dudek, Christian-Alexander Boers, Hanny M. Meyer-Hermann, Michael Jacobs, Doris M. Hiller, Karsten |
author_facet | Schlicker, Lisa Zhao, Gang Dudek, Christian-Alexander Boers, Hanny M. Meyer-Hermann, Michael Jacobs, Doris M. Hiller, Karsten |
author_sort | Schlicker, Lisa |
collection | PubMed |
description | On an organismal level, metabolism needs to react in a well-orchestrated manner to metabolic challenges such as nutrient uptake. Key metabolic hubs in human blood are pyruvate and lactate, both of which are constantly interconverted by very fast exchange fluxes. The quantitative contribution of different food sources to these metabolite pools remains unclear. Here, we applied in vivo stable isotope labeling to determine postprandial metabolic fluxes in response to two carbohydrate sources of different complexity. Depending on the ingested carbohydrate source, glucose or wheat flour, the net direction of the lactate dehydrogenase, and the alanine amino transferase fluxes were adjusted in a way to ensure sufficient availability, while, at the same time, preventing an overflow in the respective metabolite pools. The systemic lactate pool acts as a metabolic buffer which is fueled in the early- and depleted in the late-postprandial phase and thus plays a key role for systemic metabolic homeostasis. |
format | Online Article Text |
id | pubmed-8961325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89613252022-03-30 Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase Schlicker, Lisa Zhao, Gang Dudek, Christian-Alexander Boers, Hanny M. Meyer-Hermann, Michael Jacobs, Doris M. Hiller, Karsten Front Nutr Nutrition On an organismal level, metabolism needs to react in a well-orchestrated manner to metabolic challenges such as nutrient uptake. Key metabolic hubs in human blood are pyruvate and lactate, both of which are constantly interconverted by very fast exchange fluxes. The quantitative contribution of different food sources to these metabolite pools remains unclear. Here, we applied in vivo stable isotope labeling to determine postprandial metabolic fluxes in response to two carbohydrate sources of different complexity. Depending on the ingested carbohydrate source, glucose or wheat flour, the net direction of the lactate dehydrogenase, and the alanine amino transferase fluxes were adjusted in a way to ensure sufficient availability, while, at the same time, preventing an overflow in the respective metabolite pools. The systemic lactate pool acts as a metabolic buffer which is fueled in the early- and depleted in the late-postprandial phase and thus plays a key role for systemic metabolic homeostasis. Frontiers Media S.A. 2022-03-10 /pmc/articles/PMC8961325/ /pubmed/35360693 http://dx.doi.org/10.3389/fnut.2022.785999 Text en Copyright © 2022 Schlicker, Zhao, Dudek, Boers, Meyer-Hermann, Jacobs and Hiller. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Schlicker, Lisa Zhao, Gang Dudek, Christian-Alexander Boers, Hanny M. Meyer-Hermann, Michael Jacobs, Doris M. Hiller, Karsten Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase |
title | Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase |
title_full | Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase |
title_fullStr | Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase |
title_full_unstemmed | Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase |
title_short | Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase |
title_sort | systemic lactate acts as a metabolic buffer in humans and prevents nutrient overflow in the postprandial phase |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961325/ https://www.ncbi.nlm.nih.gov/pubmed/35360693 http://dx.doi.org/10.3389/fnut.2022.785999 |
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