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Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis

Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world’s aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients’ pain. However, several studies have noted that while these...

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Autores principales: Bharat, Krish Tejas, Manhas, Navdeep Singh, Gutcho, James, Lin, Joshua, Bhattacharyya, Sumon, Kounang, Robertus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961370/
https://www.ncbi.nlm.nih.gov/pubmed/35360183
http://dx.doi.org/10.1177/11795441211063365
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author Bharat, Krish Tejas
Manhas, Navdeep Singh
Gutcho, James
Lin, Joshua
Bhattacharyya, Sumon
Kounang, Robertus
author_facet Bharat, Krish Tejas
Manhas, Navdeep Singh
Gutcho, James
Lin, Joshua
Bhattacharyya, Sumon
Kounang, Robertus
author_sort Bharat, Krish Tejas
collection PubMed
description Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world’s aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients’ pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use. Recently, due to their more favorable side-effect profiles, herbal alternatives for controlling osteoarthritis symptoms and for alleviating the progression of the disease are being increasingly studied. Synogesic is a newly developed herbal supplement blend by renowned orthopedic surgeons and physiatrists consisting of turmeric, rutin, ginger root, vitamin C, vitamin D, and boswellia extracts. A study by Sharkey et al. has commented on the efficacy of the blend on the patients with knee osteoarthritis. So far, a review on the ingredients of the blend has not yet carried outbeen. By exploring prominent literature databases including PubMed and ScienceDirect, our aim is to write a narrative review to explore the individual ingredients of this blend and delve into their characteristics, as well as the most recent literature on their mechanism and efficacy in patients with osteoarthritis. Through this, we hope to inform clinicians and patients alike on relevant up-to-date research on the supplement and provide insight on the potential for this supplement for alleviating the disease course of patients with osteoarthritis.
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spelling pubmed-89613702022-03-30 Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis Bharat, Krish Tejas Manhas, Navdeep Singh Gutcho, James Lin, Joshua Bhattacharyya, Sumon Kounang, Robertus Clin Med Insights Arthritis Musculoskelet Disord Review Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world’s aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients’ pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use. Recently, due to their more favorable side-effect profiles, herbal alternatives for controlling osteoarthritis symptoms and for alleviating the progression of the disease are being increasingly studied. Synogesic is a newly developed herbal supplement blend by renowned orthopedic surgeons and physiatrists consisting of turmeric, rutin, ginger root, vitamin C, vitamin D, and boswellia extracts. A study by Sharkey et al. has commented on the efficacy of the blend on the patients with knee osteoarthritis. So far, a review on the ingredients of the blend has not yet carried outbeen. By exploring prominent literature databases including PubMed and ScienceDirect, our aim is to write a narrative review to explore the individual ingredients of this blend and delve into their characteristics, as well as the most recent literature on their mechanism and efficacy in patients with osteoarthritis. Through this, we hope to inform clinicians and patients alike on relevant up-to-date research on the supplement and provide insight on the potential for this supplement for alleviating the disease course of patients with osteoarthritis. SAGE Publications 2022-03-25 /pmc/articles/PMC8961370/ /pubmed/35360183 http://dx.doi.org/10.1177/11795441211063365 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Bharat, Krish Tejas
Manhas, Navdeep Singh
Gutcho, James
Lin, Joshua
Bhattacharyya, Sumon
Kounang, Robertus
Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis
title Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis
title_full Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis
title_fullStr Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis
title_full_unstemmed Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis
title_short Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis
title_sort ingredients of a natural oral nutritional supplement and their role in the treatment of osteoarthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961370/
https://www.ncbi.nlm.nih.gov/pubmed/35360183
http://dx.doi.org/10.1177/11795441211063365
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