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Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development

MG53 is an essential component of the cell membrane repair machinery, participating in the healing of dermal wounds. Here we develop a novel delivery system using recombinant human MG53 (rhMG53) protein and a reactive oxygen species (ROS)-scavenging gel to treat diabetic wounds. Mice with ablation o...

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Detalles Bibliográficos
Autores principales: Niu, Hong, Li, Haichang, Guan, Ya, Zhou, Xin, Li, Zhongguang, Zhao, Serana Li, Chen, Peng, Tan, Tao, Zhu, Hua, Bergdall, Valerie, Xu, Xuehong, Ma, Jianjie, Guan, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961467/
https://www.ncbi.nlm.nih.gov/pubmed/35387169
http://dx.doi.org/10.1016/j.bioactmat.2022.03.017
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author Niu, Hong
Li, Haichang
Guan, Ya
Zhou, Xin
Li, Zhongguang
Zhao, Serana Li
Chen, Peng
Tan, Tao
Zhu, Hua
Bergdall, Valerie
Xu, Xuehong
Ma, Jianjie
Guan, Jianjun
author_facet Niu, Hong
Li, Haichang
Guan, Ya
Zhou, Xin
Li, Zhongguang
Zhao, Serana Li
Chen, Peng
Tan, Tao
Zhu, Hua
Bergdall, Valerie
Xu, Xuehong
Ma, Jianjie
Guan, Jianjun
author_sort Niu, Hong
collection PubMed
description MG53 is an essential component of the cell membrane repair machinery, participating in the healing of dermal wounds. Here we develop a novel delivery system using recombinant human MG53 (rhMG53) protein and a reactive oxygen species (ROS)-scavenging gel to treat diabetic wounds. Mice with ablation of MG53 display defective hair follicle structure, and topical application of rhMG53 can promote hair growth in the mg53(−/−) mice. Cell lineage tracing studies reveal a physiological function of MG53 in modulating the proliferation of hair follicle stem cells (HFSCs). We find that rhMG53 protects HFSCs from oxidative stress-induced apoptosis and stimulates differentiation of HSFCs into keratinocytes. The cytoprotective function of MG53 is mediated by STATs and MAPK signaling in HFSCs. The thermosensitive ROS-scavenging gel encapsulated with rhMG53 allows for sustained release of rhMG53 and promotes healing of chronic cutaneous wounds and hair follicle development in the db/db mice. These findings support the potential therapeutic value of using rhMG53 in combination with ROS-scavenging gel to treat diabetic wounds.
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spelling pubmed-89614672022-04-05 Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development Niu, Hong Li, Haichang Guan, Ya Zhou, Xin Li, Zhongguang Zhao, Serana Li Chen, Peng Tan, Tao Zhu, Hua Bergdall, Valerie Xu, Xuehong Ma, Jianjie Guan, Jianjun Bioact Mater Article MG53 is an essential component of the cell membrane repair machinery, participating in the healing of dermal wounds. Here we develop a novel delivery system using recombinant human MG53 (rhMG53) protein and a reactive oxygen species (ROS)-scavenging gel to treat diabetic wounds. Mice with ablation of MG53 display defective hair follicle structure, and topical application of rhMG53 can promote hair growth in the mg53(−/−) mice. Cell lineage tracing studies reveal a physiological function of MG53 in modulating the proliferation of hair follicle stem cells (HFSCs). We find that rhMG53 protects HFSCs from oxidative stress-induced apoptosis and stimulates differentiation of HSFCs into keratinocytes. The cytoprotective function of MG53 is mediated by STATs and MAPK signaling in HFSCs. The thermosensitive ROS-scavenging gel encapsulated with rhMG53 allows for sustained release of rhMG53 and promotes healing of chronic cutaneous wounds and hair follicle development in the db/db mice. These findings support the potential therapeutic value of using rhMG53 in combination with ROS-scavenging gel to treat diabetic wounds. KeAi Publishing 2022-03-16 /pmc/articles/PMC8961467/ /pubmed/35387169 http://dx.doi.org/10.1016/j.bioactmat.2022.03.017 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Niu, Hong
Li, Haichang
Guan, Ya
Zhou, Xin
Li, Zhongguang
Zhao, Serana Li
Chen, Peng
Tan, Tao
Zhu, Hua
Bergdall, Valerie
Xu, Xuehong
Ma, Jianjie
Guan, Jianjun
Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
title Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
title_full Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
title_fullStr Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
title_full_unstemmed Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
title_short Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development
title_sort sustained delivery of rhmg53 promotes diabetic wound healing and hair follicle development
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961467/
https://www.ncbi.nlm.nih.gov/pubmed/35387169
http://dx.doi.org/10.1016/j.bioactmat.2022.03.017
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