Cargando…

Viral dUTPases: Modulators of Innate Immunity

Most free-living organisms encode for a deoxyuridine triphosphate nucleotidohydrolase (dUTPase; EC 3.6.1.23). dUTPases represent a family of metalloenzymes that catalyze the hydrolysis of dUTP to dUMP and pyrophosphate, preventing dUTP from being incorporated into DNA by DNA polymerases, maintaining...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ariza, Maria Eugenia, Cox, Brandon, Martinez, Britney, Mena-Palomo, Irene, Zarate, Gloria Jeronimo, Williams, Marshall Vance
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961515/ https://www.ncbi.nlm.nih.gov/pubmed/35204728 http://dx.doi.org/10.3390/biom12020227

Ejemplares similares

EBV dUTPase: A Novel Modulator of Inflammation and the Tumor Microenvironment in EBV-Associated Malignancies
por: Williams, Marshall V., et al.
Publicado: (2023)

Human herpesviruses-encoded dUTPases: a family of proteins that modulate dendritic cell function and innate immunity
por: Ariza, Maria Eugenia, et al.
Publicado: (2014)

EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing T(FH) cell differentiation and extrafollicular activities
por: Cox, Brandon S., et al.
Publicado: (2022)

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease
por: Williams, Marshall V., et al.
Publicado: (2016)

Life without dUTPase
por: Kerepesi, Csaba, et al.
Publicado: (2016)

Epstein-Barr Virus Encoded dUTPase Containing Exosomes Modulate Innate and Adaptive Immune Responses in Human Dendritic Cells and Peripheral Blood Mononuclear Cells
por: Ariza, Maria Eugenia, et al.
Publicado: (2013)

The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein
por: Voronin, Nickolay, et al.
Publicado: (2014)

EBV Positive Diffuse Large B Cell Lymphoma and Chronic Lymphocytic Leukemia Patients Exhibit Increased Anti-dUTPase Antibodies
por: Williams, Marshall, et al.
Publicado: (2018)

Protective Effect of Human Endogenous Retrovirus K dUTPase Variants on Psoriasis Susceptibility
por: Lai, Olivia Y., et al.
Publicado: (2012)

The dUTPase Enzyme Is Essential in Mycobacterium smegmatis
por: Pecsi, Ildiko, et al.
Publicado: (2012)

Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins
por: Németh-Pongrácz, Veronika, et al.
Publicado: (2007)

Examination of control asymptomatic cohorts reveals heightened anti‐EBV and HHV‐6 A/B dUTPase antibodies in the aging populations
por: Alharshawi, Khaled, et al.
Publicado: (2022)

Homologous Recombination Is Stimulated by a Decrease in dUTPase in Arabidopsis
por: Dubois, Emeline, et al.
Publicado: (2011)

dUTPase: the frequently overlooked enzyme encoded by many retroviruses
por: Hizi, Amnon, et al.
Publicado: (2015)

Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis
por: Alam, Md. Shahanoor, et al.
Publicado: (2019)

dUTPase inhibition augments replication defects of 5-Fluorouracil
por: Hagenkort, Anna, et al.
Publicado: (2017)

dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae
por: Guillet, Marie, et al.
Publicado: (2006)

Erratum to: dUTPase: the frequently overlooked enzyme encoded by many retroviruses
por: Hizi, Amnon, et al.
Publicado: (2015)

Structural model of human dUTPase in complex with a novel proteinaceous inhibitor
por: Nyíri, Kinga, et al.
Publicado: (2018)

Convergent evolution involving dimeric and trimeric dUTPases in pathogenicity island mobilization
por: Donderis, Jorge, et al.
Publicado: (2017)

Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus
por: Chia, Catherine P., et al.
Publicado: (2020)

The Anti-interferon Activity of Conserved Viral dUTPase ORF54 is Essential for an Effective MHV-68 Infection
por: Leang, Ronika Sitapara, et al.
Publicado: (2011)

Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition
por: Otsuki, Shoichiro, et al.
Publicado: (2021)

Aromatic stacking between nucleobase and enzyme promotes phosphate ester hydrolysis in dUTPase
por: Pecsi, Ildiko, et al.
Publicado: (2010)

The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase
por: Benedek, András, et al.
Publicado: (2017)

Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies
por: Zhang, Shuai, et al.
Publicado: (2021)

Molecular Characterization of UL50 (dUTPase) Gene of Bovine Herpes Virus 1
por: Shahin, Farzana, et al.
Publicado: (2023)

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitorD9331
por: Webley, S D, et al.
Publicado: (2000)

Higher expression of deoxyuridine triphosphatase (dUTPase) may predict the metastasis potential of colorectal cancer
por: Kawahara, A, et al.
Publicado: (2009)

Calpain-Catalyzed Proteolysis of Human dUTPase Specifically Removes the Nuclear Localization Signal Peptide
por: Bozóky, Zoltán, et al.
Publicado: (2011)

The Role of a Key Amino Acid Position in Species-Specific Proteinaceous dUTPase Inhibition
por: Benedek, András, et al.
Publicado: (2019)

Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes
por: Hirmondo, Rita, et al.
Publicado: (2017)

The Bacteriophage–Phage-Inducible Chromosomal Island Arms Race Designs an Interkingdom Inhibitor of dUTPases
por: Sanz-Frasquet, Carla, et al.
Publicado: (2023)

CRISPR/Cas9-Mediated Knock-Out of dUTPase in Mice Leads to Early Embryonic Lethality
por: Pálinkás, Hajnalka Laura, et al.
Publicado: (2019)

Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity
por: Pérez-Moreno, Guiomar, et al.
Publicado: (2019)

Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target
por: Li, Changyao, et al.
Publicado: (2019)

Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase()
por: Hampton, Shahienaz E., et al.
Publicado: (2013)

Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80α dUTPase
por: Alite, Christian, et al.
Publicado: (2017)

Structural comparisons of host and African swine fever virus dUTPases reveal new clues for inhibitor development
por: Liang, Rui, et al.
Publicado: (2020)

Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome
por: Dong, Qiwen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_l3r4kbjiqj46tfro9bushsm62q