Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death

The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly...

Descripción completa

Detalles Bibliográficos
Autores principales: Lalier, Lisenn, Vallette, François, Manon, Stéphen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961529/
https://www.ncbi.nlm.nih.gov/pubmed/35204663
http://dx.doi.org/10.3390/biom12020162
_version_ 1784677615257255936
author Lalier, Lisenn
Vallette, François
Manon, Stéphen
author_facet Lalier, Lisenn
Vallette, François
Manon, Stéphen
author_sort Lalier, Lisenn
collection PubMed
description The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM)) in the mitochondrial localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting cells and in cells committed into apoptosis.
format Online
Article
Text
id pubmed-8961529
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89615292022-03-30 Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death Lalier, Lisenn Vallette, François Manon, Stéphen Biomolecules Review The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM)) in the mitochondrial localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting cells and in cells committed into apoptosis. MDPI 2022-01-19 /pmc/articles/PMC8961529/ /pubmed/35204663 http://dx.doi.org/10.3390/biom12020162 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lalier, Lisenn
Vallette, François
Manon, Stéphen
Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
title Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
title_full Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
title_fullStr Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
title_full_unstemmed Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
title_short Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
title_sort bcl-2 family members and the mitochondrial import machineries: the roads to death
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961529/
https://www.ncbi.nlm.nih.gov/pubmed/35204663
http://dx.doi.org/10.3390/biom12020162
work_keys_str_mv AT lalierlisenn bcl2familymembersandthemitochondrialimportmachineriestheroadstodeath
AT vallettefrancois bcl2familymembersandthemitochondrialimportmachineriestheroadstodeath
AT manonstephen bcl2familymembersandthemitochondrialimportmachineriestheroadstodeath

Ejemplares similares