Cargando…

N-Acylated and N-Alkylated 2-Aminobenzothiazoles Are Novel Agents That Suppress the Generation of Prostaglandin E(2)

The quest for novel agents to regulate the generation of prostaglandin E(2) (PGE(2)) is of high importance because this eicosanoid is a key player in inflammatory diseases. We synthesized a series of N-acylated and N-alkylated 2-aminobenzothiazoles and related heterocycles (benzoxazoles and benzimid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Theodoropoulou, Maria A., Psarra, Anastasia, Erhardt, Martin, Nikolaou, Aikaterini, Gerogiannopoulou, Anna-Dimitra D., Hadjipavlou-Litina, Dimitra, Hayashi, Daiki, Dennis, Edward A., Huwiler, Andrea, Kokotos, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961538/ https://www.ncbi.nlm.nih.gov/pubmed/35204768 http://dx.doi.org/10.3390/biom12020267

Ejemplares similares

α-Ketoheterocycles Able to Inhibit the Generation of Prostaglandin E(2) (PGE(2)) in Rat Mesangial Cells
por: Psarra, Anastasia, et al.
Publicado: (2021)

The Occurrence of Flavonoids and Related Compounds in Cedrus brevifolia A. Henry ex Elwes & A. Henry Needles. Inhibitory Potencies on Lipoxygenase, Linoleic Acid Lipid Peroxidation and Antioxidant Activity
por: Douros, Andreas, et al.
Publicado: (2017)

Multitarget Molecular Hybrids of Cinnamic Acids
por: Peperidou, Aikaterini, et al.
Publicado: (2014)

2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities †
por: Kouzi, Olympia, et al.
Publicado: (2019)

Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies
por: Pontiki, Eleni, et al.
Publicado: (2018)

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids
por: Chainoglou, Eirini, et al.
Publicado: (2020)

Photochemical [2 + 2] Cycloaddition of Alkenes with Maleimides: Highlighting the Differences between N-Alkyl vs N-Aryl Maleimides
por: Skolia, Elpida, et al.
Publicado: (2022)

Isothioureas, Ureas, and Their N-Methyl Amides from 2-Aminobenzothiazole and Chiral Amino Acids
por: Padilla-Martínez, Itzia I., et al.
Publicado: (2019)

Novel 6- and 7-Substituted Coumarins with Inhibitory Action against Lipoxygenase and Tumor-Associated Carbonic Anhydrase IX
por: Peperidou, Aikaterini, et al.
Publicado: (2018)

Multifunctional Cinnamic Acid Derivatives
por: Peperidou, Aikaterini, et al.
Publicado: (2017)

Hybrids as NO Donors
por: Tsopka, Ioanna-Chrysoula, et al.
Publicado: (2021)

Cu(ii)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature
por: Radhika, Sankaran, et al.
Publicado: (2023)

Bis(2-aminobenzothiazole-κN (1))bis(thiocyanato-κN)zinc(II)
por: Suh, Seung Wook, et al.
Publicado: (2009)

Synthesis of biologically active derivatives of 2-aminobenzothiazole
por: Zhilitskaya, Larisa V., et al.
Publicado: (2021)

Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives
por: Konstantinidou, Markella, et al.
Publicado: (2015)

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
por: Mantzanidou, Martha, et al.
Publicado: (2021)

Antioxidant Activity of 3-[N-(Acylhydrazono)ethyl]-4-hydroxy-coumarins
por: Kotali, Antigoni, et al.
Publicado: (2016)

Small Peptides Able to Suppress Prostaglandin E(2) Generation in Renal Mesangial Cells
por: Vasilakaki, Sofia, et al.
Publicado: (2018)

Boronic Acid Group: A Cumbersome False Negative Case in the Process of Drug Design
por: Katsamakas, Sotirios, et al.
Publicado: (2016)

Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones
por: Hadjipavlou-Litina, Dimitra, et al.
Publicado: (2022)

Organosilicon-Containing Thiazole Derivatives as Potential Lipoxygenase Inhibitors and Anti-Inflammatory Agents
por: Geronikaki, Athina, et al.
Publicado: (2007)

Novel Cinnamic Acid Derivatives as Antioxidant and Anticancer Agents: Design, Synthesis and Modeling Studies
por: Pontiki, Eleni, et al.
Publicado: (2014)

5-(4H)-Oxazolones and Their Benzamides as Potential Bioactive Small Molecules
por: Mavridis, Evangelos, et al.
Publicado: (2020)

Hybridization of Curcumin Analogues with Cinnamic Acid Derivatives as Multi-Target Agents Against Alzheimer’s Disease Targets
por: Chainoglou, Eirini, et al.
Publicado: (2020)

Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones
por: Piotrowska, Dorota G., et al.
Publicado: (2019)

Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties
por: Pontiki, Eleni, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties
por: Kallitsakis, Michael G., et al.
Publicado: (2017)

The novel amidocarbamate derivatives of ketoprofen: synthesis and biological activity
por: Rajić, Zrinka, et al.
Publicado: (2010)

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants
por: Perković, I., et al.
Publicado: (2012)

Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties
por: Diez-Iriepa, Daniel, et al.
Publicado: (2020)

Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
por: Thimaradka, Vikram, et al.
Publicado: (2021)

Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate
por: Gao, Hong, et al.
Publicado: (2013)

Substituted 2-Aminobenzothiazoles Salicylidenes Synthesis and Characterization as Cyanide Sensors in Aqueous Medium
por: Elsafy, Anas G., et al.
Publicado: (2018)

Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition of Pseudomonas aeruginosa Virulence Phenotypes
por: Fihn, Conrad A., et al.
Publicado: (2023)

Insights into biological activity of ureidoamides with primaquine and amino acid moieties
por: Vlainić, Josipa, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of New 4,5-Disubstituted-Thiazolyl Amides, Derivatives of 4-Hydroxy-Piperidine or of 4-N-Methyl Piperazine
por: Geronikaki, A., et al.
Publicado: (2003)

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1′-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models
por: Chamorro, Beatriz, et al.
Publicado: (2021)

Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide
por: Tamura, Tomonori, et al.
Publicado: (2018)

Synthesis and Antioxidant Properties of HeteroBisNitrones Derived from Benzene Dicarbaldehydes
por: Diez-Iriepa, Daniel, et al.
Publicado: (2022)

Reagent-controlled regiodivergent intermolecular cyclization of 2-aminobenzothiazoles with β-ketoesters and β-ketoamides
por: Roslan, Irwan Iskandar, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ep4al4mcuo42oo19ehg8odr2td