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Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital

OBJECTIVES: We sought to identify the most commonly used antihypertensive medications in pregnant women and to determine the impact of these medications on perinatal (maternal and fetal) outcomes. METHODS: The medical records of 484 hypertensive pregnant women who attended a tertiary university hosp...

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Autores principales: Al Ismaili, Al-khatab, Al-Duqhaishi, Tamima, Al Rajaibi, Hajar, Al Waili, Khalid, Al Rasadi, Khalid, Nadar, Sunail K., Al Hashmi, Khamis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OMJ 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961539/
https://www.ncbi.nlm.nih.gov/pubmed/35356366
http://dx.doi.org/10.5001/omj.2022.43
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author Al Ismaili, Al-khatab
Al-Duqhaishi, Tamima
Al Rajaibi, Hajar
Al Waili, Khalid
Al Rasadi, Khalid
Nadar, Sunail K.
Al Hashmi, Khamis
author_facet Al Ismaili, Al-khatab
Al-Duqhaishi, Tamima
Al Rajaibi, Hajar
Al Waili, Khalid
Al Rasadi, Khalid
Nadar, Sunail K.
Al Hashmi, Khamis
author_sort Al Ismaili, Al-khatab
collection PubMed
description OBJECTIVES: We sought to identify the most commonly used antihypertensive medications in pregnant women and to determine the impact of these medications on perinatal (maternal and fetal) outcomes. METHODS: The medical records of 484 hypertensive pregnant women who attended a tertiary university hospital during the study period were retrospectively evaluated for eligibility. Singleton pregnancies of women on antihypertensive medications and who delivered in the hospital were included in the study. RESULTS: A total of 210 women (mean age of 32.4±5.6 years and mean body mass index of 34.0±8.1 kg/m(2)) were eligible for inclusion in the study. The most prevalent subtype of hypertension was preeclampsia (41.4%). Low birth weight (LBW), preterm delivery (PTD), intrauterine growth restriction (IUGR), small for gestational age (SGA), respiratory distress syndrome, and neonatal care unit admissions were significantly higher in women with preeclampsia than in the women with other types of hypertension. Labetalol was the most commonly prescribed antihypertensive drug. There were 101 (48.1%) women on combined therapy. LBW, PTD, IUGR, SGA, respiratory distress syndrome, absent end diastolic flow, neonatal care unit admission, preeclampsia, and high dependency unit admissions of mothers were significantly higher in the women who received combined therapy. CONCLUSIONS: Labetalol was the most commonly prescribed antihypertensive drug in this cohort, and women on combined antihypertensive medications had significantly higher maternal and fetal complications. A larger prospective study including hypertensive women with or without antihypertensive medications in more than one center is needed to evaluate the effect of these drugs on perinatal outcomes.
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spelling pubmed-89615392022-03-29 Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital Al Ismaili, Al-khatab Al-Duqhaishi, Tamima Al Rajaibi, Hajar Al Waili, Khalid Al Rasadi, Khalid Nadar, Sunail K. Al Hashmi, Khamis Oman Med J Original Articles OBJECTIVES: We sought to identify the most commonly used antihypertensive medications in pregnant women and to determine the impact of these medications on perinatal (maternal and fetal) outcomes. METHODS: The medical records of 484 hypertensive pregnant women who attended a tertiary university hospital during the study period were retrospectively evaluated for eligibility. Singleton pregnancies of women on antihypertensive medications and who delivered in the hospital were included in the study. RESULTS: A total of 210 women (mean age of 32.4±5.6 years and mean body mass index of 34.0±8.1 kg/m(2)) were eligible for inclusion in the study. The most prevalent subtype of hypertension was preeclampsia (41.4%). Low birth weight (LBW), preterm delivery (PTD), intrauterine growth restriction (IUGR), small for gestational age (SGA), respiratory distress syndrome, and neonatal care unit admissions were significantly higher in women with preeclampsia than in the women with other types of hypertension. Labetalol was the most commonly prescribed antihypertensive drug. There were 101 (48.1%) women on combined therapy. LBW, PTD, IUGR, SGA, respiratory distress syndrome, absent end diastolic flow, neonatal care unit admission, preeclampsia, and high dependency unit admissions of mothers were significantly higher in the women who received combined therapy. CONCLUSIONS: Labetalol was the most commonly prescribed antihypertensive drug in this cohort, and women on combined antihypertensive medications had significantly higher maternal and fetal complications. A larger prospective study including hypertensive women with or without antihypertensive medications in more than one center is needed to evaluate the effect of these drugs on perinatal outcomes. OMJ 2022-03-22 /pmc/articles/PMC8961539/ /pubmed/35356366 http://dx.doi.org/10.5001/omj.2022.43 Text en The OMJ is Published Bimonthly and Copyrighted 2022 by the OMSB. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License. http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Original Articles
Al Ismaili, Al-khatab
Al-Duqhaishi, Tamima
Al Rajaibi, Hajar
Al Waili, Khalid
Al Rasadi, Khalid
Nadar, Sunail K.
Al Hashmi, Khamis
Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital
title Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital
title_full Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital
title_fullStr Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital
title_full_unstemmed Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital
title_short Antihypertensive Drugs and Perinatal Outcomes in Hypertensive Women Attending a Specialized Tertiary Hospital
title_sort antihypertensive drugs and perinatal outcomes in hypertensive women attending a specialized tertiary hospital
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961539/
https://www.ncbi.nlm.nih.gov/pubmed/35356366
http://dx.doi.org/10.5001/omj.2022.43
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