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Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD is characterized by changes in the behavior of the genome and can be traced across multiple brain regions and cell types. It is mainly associ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961579/ https://www.ncbi.nlm.nih.gov/pubmed/35204764 http://dx.doi.org/10.3390/biom12020263 |
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author | Dovrolis, Nikolas Nikou, Maria Gkrouzoudi, Alexandra Dimitriadis, Nikolaos Maroulakou, Ioanna |
author_facet | Dovrolis, Nikolas Nikou, Maria Gkrouzoudi, Alexandra Dimitriadis, Nikolaos Maroulakou, Ioanna |
author_sort | Dovrolis, Nikolas |
collection | PubMed |
description | Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD is characterized by changes in the behavior of the genome and can be traced across multiple brain regions and cell types. It is mainly associated with β-amyloid deposits and tau protein misfolding, leading to neurofibrillary tangles. In recent years, however, research has shown that there is a high complexity of mechanisms involved in AD neurophysiology and functional decline enabling its diverse presentation and allowing more questions to arise. In this study, we present a computational approach to facilitate brain region-specific analysis of genes and biological processes involved in the memory process in AD. Utilizing current genetic knowledge we provide a gene set of 265 memory-associated genes in AD, combinations of which can be found co-expressed in 11 different brain regions along with their functional role. The identified genes participate in a spectrum of biological processes ranging from structural and neuronal communication to epigenetic alterations and immune system responses. These findings provide new insights into the molecular background of AD and can be used to bridge the genotype–phenotype gap and allow for new therapeutic hypotheses. |
format | Online Article Text |
id | pubmed-8961579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89615792022-03-30 Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions Dovrolis, Nikolas Nikou, Maria Gkrouzoudi, Alexandra Dimitriadis, Nikolaos Maroulakou, Ioanna Biomolecules Article Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and a general cognitive decline leading to dementia. AD is characterized by changes in the behavior of the genome and can be traced across multiple brain regions and cell types. It is mainly associated with β-amyloid deposits and tau protein misfolding, leading to neurofibrillary tangles. In recent years, however, research has shown that there is a high complexity of mechanisms involved in AD neurophysiology and functional decline enabling its diverse presentation and allowing more questions to arise. In this study, we present a computational approach to facilitate brain region-specific analysis of genes and biological processes involved in the memory process in AD. Utilizing current genetic knowledge we provide a gene set of 265 memory-associated genes in AD, combinations of which can be found co-expressed in 11 different brain regions along with their functional role. The identified genes participate in a spectrum of biological processes ranging from structural and neuronal communication to epigenetic alterations and immune system responses. These findings provide new insights into the molecular background of AD and can be used to bridge the genotype–phenotype gap and allow for new therapeutic hypotheses. MDPI 2022-02-06 /pmc/articles/PMC8961579/ /pubmed/35204764 http://dx.doi.org/10.3390/biom12020263 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dovrolis, Nikolas Nikou, Maria Gkrouzoudi, Alexandra Dimitriadis, Nikolaos Maroulakou, Ioanna Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions |
title | Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions |
title_full | Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions |
title_fullStr | Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions |
title_full_unstemmed | Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions |
title_short | Unlocking the Memory Component of Alzheimer’s Disease: Biological Processes and Pathways across Brain Regions |
title_sort | unlocking the memory component of alzheimer’s disease: biological processes and pathways across brain regions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961579/ https://www.ncbi.nlm.nih.gov/pubmed/35204764 http://dx.doi.org/10.3390/biom12020263 |
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