Macrophage-like THP-1 Cells Derived from High-Density Cell Culture Are Resistant to TRAIL-Induced Cell Death via Down-Regulation of Death-Receptors DR4 and DR5

SIMPLE SUMMARY: The mechanisms of leukemic cell resistance to antitumor immunity remains a topical issue. In this work, we found an increase in TRAIL-resistance of human acute myeloid leukemia cells THP-1 in high-density populations in vitro. The results obtained show that a macrophage-like phenotyp...

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Detalles Bibliográficos
Autores principales: Lomovskaya, Yana Vladimirovna, Kobyakova, Margarita Igorevna, Senotov, Anatoly Sergeevich, Lomovsky, Alexey Igorevich, Minaychev, Vladislav Valentinovich, Fadeeva, Irina Sergeevna, Shtatnova, Daria Yuryevna, Krasnov, Kirill Sergeevich, Zvyagina, Alena Igorevna, Akatov, Vladimir Semenovich, Fadeev, Roman Sergeevich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961584/
https://www.ncbi.nlm.nih.gov/pubmed/35204655
http://dx.doi.org/10.3390/biom12020150

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