Inhibition of Polyglutamine Misfolding with D-Enantiomeric Peptides Identified by Mirror Image Phage Display Selection

Nine heritable diseases are known that are caused by unphysiologically elongated polyglutamine tracts in human proteins leading to misfolding, aggregation and neurodegeneration. Current therapeutic strategies include efforts to inhibit the expression of the respective gene coding for the polyglutami...

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Detalles Bibliográficos
Autores principales: Kolkwitz, Pauline Elisabeth, Mohrlüder, Jeannine, Willbold, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961585/
https://www.ncbi.nlm.nih.gov/pubmed/35204656
http://dx.doi.org/10.3390/biom12020157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961585/
https://www.ncbi.nlm.nih.gov/pubmed/35204656
http://dx.doi.org/10.3390/biom12020157

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