Cargando…

A New Approach to Inhibiting Triple-Negative Breast Cancer: In Vitro, Ex Vivo and In Vivo Antiangiogenic Effect of BthTx-II, a PLA(2)-Asp-49 from Bothrops jararacussu Venom

Phospholipases A(2) (PLA(2)) represent a superfamily of enzymes widely distributed in living organisms, with a broad spectrum of pharmacological activities and therapeutic potential. Anti-angiogenic strategies have become one of the main tools in fighting cancer. In this sense, the present work repo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Van Petten de Vasconcelos Azevedo, Fernanda, Lopes, Daiana Silva, Zóia, Mariana Alves Pereira, Correia, Lucas Ian Veloso, Saito, Natieli, Fonseca, Belchiolina Beatriz, Polloni, Lorena, Teixeira, Samuel Cota, Goulart, Luiz Ricardo, de Melo Rodrigues Ávila, Veridiana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961627/ https://www.ncbi.nlm.nih.gov/pubmed/35204758 http://dx.doi.org/10.3390/biom12020258

Ejemplares similares

Linear B-cell epitopes in BthTX-I, BthTX-II and BthA-I, phospholipase A(2's )from Bothrops jararacussu snake venom, recognized by therapeutically neutralizing commercial horse antivenom
por: De-Simone, Salvatore, et al.
Publicado: (2014)

BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation
por: Bezerra, Patrícia Heloise Alves, et al.
Publicado: (2019)

Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines
por: Prinholato da Silva, Cássio, et al.
Publicado: (2015)

Antibacterial Activity of the Non-Cytotoxic Peptide (p-BthTX-I)(2) and Its Serum Degradation Product against Multidrug-Resistant Bacteria
por: Santos-Filho, Norival A., et al.
Publicado: (2017)

Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PL(pro) Protein
por: Bitencourt, Natália Vitória, et al.
Publicado: (2023)

The Triterpenoid Betulin Protects against the Neuromuscular Effects of Bothrops jararacussu Snake Venom In Vivo
por: Ferraz, Miriéle Cristina, et al.
Publicado: (2015)

Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms?
por: Araujo, Ricardo Teixeira, et al.
Publicado: (2017)

Inhibition of Bothrops jararacussu venom activities by Plathymenia reticulata Benth extracts
por: Farrapo, Nicole M, et al.
Publicado: (2011)

A C-Type Lectin from Bothrops jararacussu Venom Disrupts Staphylococcal Biofilms
por: Klein, Raphael Contelli, et al.
Publicado: (2015)

Pulsed ultrasound therapy accelerates the recovery of skeletal muscle damage induced by Bothrops jararacussu venom
por: Saturnino-Oliveira, J., et al.
Publicado: (2012)

Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom
por: Puebla, Pilar, et al.
Publicado: (2010)

Size Matters: An Evaluation of the Molecular Basis of Ontogenetic Modifications in the Composition of Bothrops jararacussu Snake Venom
por: Freitas-de-Sousa, Luciana A., et al.
Publicado: (2020)

Refolding by High Pressure of a Toxin Containing Seven Disulfide Bonds: Bothropstoxin-1 from Bothrops jararacussu
por: Balduino, Keli N., et al.
Publicado: (2010)

Heparin at low concentration acts as antivenom against Bothrops jararacussu venom and bothropstoxin-I neurotoxic and myotoxic actions
por: Rostelato-Ferreira, Sandro, et al.
Publicado: (2010)

Vellozia flavicans Mart. ex Schult. hydroalcoholic extract inhibits the neuromuscular blockade induced by Bothrops jararacussu venom
por: Tribuiani, Natália, et al.
Publicado: (2014)

Human neutrophil migration and activation by BJcuL, a galactose binding lectin purified from Bothrops jararacussu venom
por: Elifio-Esposito, Selene, et al.
Publicado: (2011)

Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom
por: Alves, N.T.Q., et al.
Publicado: (2018)

Cordia salicifolia and Lafoensia pacari plant extracts against the local effects of Bothrops jararacussu and Philodryas olfersii snake venoms
por: Schezaro-Ramos, Raphael, et al.
Publicado: (2020)

Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A(2) by Specific Camelid Single-Domain Antibody Fragments
por: Prado, Nidiane D. R., et al.
Publicado: (2016)

The allosteric activation mechanism of a phospholipase A(2)-like toxin from Bothrops jararacussu venom: a dynamic description
por: Gomes, Antoniel A. S., et al.
Publicado: (2020)

In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu
por: Belchor, Mariana Novo, et al.
Publicado: (2023)

Alkylation of Histidine Residues of Bothrops jararacussu Venom Proteins and Isolated Phospholipases A(2): A Biotechnological Tool to Improve the Production of Antibodies
por: Guimarães, C. L. S., et al.
Publicado: (2014)

Light Emitting Diode Photobiomodulation Enhances Oxidative Redox Capacity in Murine Macrophages Stimulated with Bothrops jararacussu Venom and Isolated PLA(2)s
por: dos Reis, Valdison Pereira, et al.
Publicado: (2022)

Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom
por: Lisboa, Antonio, et al.
Publicado: (2016)

An Isoflavone from Dipteryx alata Vogel is Active against the in Vitro Neuromuscular Paralysis of Bothrops jararacussu Snake Venom and Bothropstoxin I, and Prevents Venom-Induced Myonecrosis
por: Ferraz, Miriéle C., et al.
Publicado: (2014)

Neutrophils activated by BJcuL, a C-type lectin isolated from Bothrops jararacussu venom, decrease the invasion potential of neuroblastoma SK-N-SH cells in vitro
por: Carneiro-Goetten, Jessica Ohana Lemes, et al.
Publicado: (2020)

Unmasking Snake Venom of Bothrops leucurus: Purification and Pharmacological and Structural Characterization of New PLA(2) Bleu TX-III
por: Marangoni, Fábio André, et al.
Publicado: (2013)

Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism
por: Salvador, Guilherme H. M., et al.
Publicado: (2018)

Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms
por: Strauch, Marcelo A., et al.
Publicado: (2019)

Antiangiogenic effects of AA-PMe on HUVECs in vitro and zebrafish in vivo
por: Jing, Yue, et al.
Publicado: (2018)

Antiangiogenic Activity of Quinine Alone and in Combination with vitamin C in both ex vivo and in vivo Assays
por: Jalil, Zainab H, et al.
Publicado: (2022)

Human neutrophils functionality under effect of an Asp49 phospholipase A(2) isolated from Bothrops atrox venom
por: Setúbal, Sulamita da S., et al.
Publicado: (2020)

Antiangiogenic Activity of Acer tegmentosum Maxim Water Extract in Vitro and in Vivo
por: Kim, Eok-Cheon, et al.
Publicado: (2015)

Molecular cloning of a hyaluronidase from Bothrops pauloensis venom gland
por: Castanheira, Letícia Eulalio, et al.
Publicado: (2014)

Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A(2) from Bothrops pirajai venom
por: Ximenes, Rafael M, et al.
Publicado: (2012)

Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells
por: Benati, Rogério Bodini, et al.
Publicado: (2018)

Shedding Lights on Crude Venom from Solitary Foraging Predatory Ant Ectatomma opaciventre: Initial Toxinological Investigation
por: Correia, Lucas Ian Veloso, et al.
Publicado: (2022)

Characterization and In Vivo Antiangiogenic Activity Evaluation of Morin-Based Cyclodextrin Inclusion Complexes
por: De Gaetano, Federica, et al.
Publicado: (2023)

In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma
por: Senrung, Anna, et al.
Publicado: (2023)

Comparison of taurine, GABA, Glu, and Asp as scavengers of malondialdehyde in vitro and in vivo
por: Deng, Yan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vhsgg38phgsj89mmahcof14vpd