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Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion

Work over the past two decades clearly defined a significant role of glycosyltransferase effectors in the infection strategy of the Gram-negative, respiratory pathogen Legionella pneumophila. Identification of the glucosyltransferase effectors Lgt1-3, specifically modifying elongation factor eEF1A,...

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Detalles Bibliográficos
Autores principales: Belyi, Yury, Levanova, Nadya, Schroeder, Gunnar N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961657/
https://www.ncbi.nlm.nih.gov/pubmed/35204756
http://dx.doi.org/10.3390/biom12020255
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author Belyi, Yury
Levanova, Nadya
Schroeder, Gunnar N.
author_facet Belyi, Yury
Levanova, Nadya
Schroeder, Gunnar N.
author_sort Belyi, Yury
collection PubMed
description Work over the past two decades clearly defined a significant role of glycosyltransferase effectors in the infection strategy of the Gram-negative, respiratory pathogen Legionella pneumophila. Identification of the glucosyltransferase effectors Lgt1-3, specifically modifying elongation factor eEF1A, disclosed a novel mechanism of host protein synthesis manipulation by pathogens and illuminated its impact on the physiological state of the target cell, in particular cell cycle progression and immune and stress responses. Recent characterization of SetA as a general O-glucosyltransferase with a wide range of targets including the proteins Rab1 and Snx1, mediators of membrane transport processes, and the discovery of new types of glycosyltransferases such as LtpM and SidI indicate that the vast effector arsenal might still hold more so-far unrecognized family members with new catalytic features and substrates. In this article, we review our current knowledge regarding these fascinating biomolecules and discuss their role in introducing new or overriding endogenous post-translational regulatory mechanisms enabling the subversion of eukaryotic cells by L. pneumophila.
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spelling pubmed-89616572022-03-30 Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion Belyi, Yury Levanova, Nadya Schroeder, Gunnar N. Biomolecules Review Work over the past two decades clearly defined a significant role of glycosyltransferase effectors in the infection strategy of the Gram-negative, respiratory pathogen Legionella pneumophila. Identification of the glucosyltransferase effectors Lgt1-3, specifically modifying elongation factor eEF1A, disclosed a novel mechanism of host protein synthesis manipulation by pathogens and illuminated its impact on the physiological state of the target cell, in particular cell cycle progression and immune and stress responses. Recent characterization of SetA as a general O-glucosyltransferase with a wide range of targets including the proteins Rab1 and Snx1, mediators of membrane transport processes, and the discovery of new types of glycosyltransferases such as LtpM and SidI indicate that the vast effector arsenal might still hold more so-far unrecognized family members with new catalytic features and substrates. In this article, we review our current knowledge regarding these fascinating biomolecules and discuss their role in introducing new or overriding endogenous post-translational regulatory mechanisms enabling the subversion of eukaryotic cells by L. pneumophila. MDPI 2022-02-04 /pmc/articles/PMC8961657/ /pubmed/35204756 http://dx.doi.org/10.3390/biom12020255 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Belyi, Yury
Levanova, Nadya
Schroeder, Gunnar N.
Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion
title Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion
title_full Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion
title_fullStr Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion
title_full_unstemmed Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion
title_short Glycosylating Effectors of Legionella pneumophila: Finding the Sweet Spots for Host Cell Subversion
title_sort glycosylating effectors of legionella pneumophila: finding the sweet spots for host cell subversion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961657/
https://www.ncbi.nlm.nih.gov/pubmed/35204756
http://dx.doi.org/10.3390/biom12020255
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