JAK2 Variant Signaling: Genetic, Hematologic and Immune Implication in Chronic Myeloproliferative Neoplasms

The JAK2V617F variant constitutes a genetic alteration of higher frequency in BCR/ABL1 negative chronic myeloproliferative neoplasms, which is caused by a substitution of a G ˃ T at position 1849 and results in the substitution of valine with phenylalanine at codon 617 of the polypeptide chain. Clin...

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Detalles Bibliográficos
Autores principales: Torres, Dania G., Paes, Jhemerson, da Costa, Allyson G., Malheiro, Adriana, Silva, George V., Mourão, Lucivana P. de Souza, Tarragô, Andréa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961666/
https://www.ncbi.nlm.nih.gov/pubmed/35204792
http://dx.doi.org/10.3390/biom12020291

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