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Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis

Cell and tissue nanomechanics, being inspired by progress in high-resolution physical mapping, has recently burst into biomedical research, discovering not only new characteristics of normal and diseased tissues, but also unveiling previously unknown mechanisms of pathological processes. Some parall...

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Autores principales: Shmelev, Mikhail E., Titov, Sergei I., Belousov, Andrei S., Farniev, Vladislav M., Zhmenia, Valeriia M., Lanskikh, Daria V., Penkova, Alina O., Kumeiko, Vadim V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961777/
https://www.ncbi.nlm.nih.gov/pubmed/35203554
http://dx.doi.org/10.3390/biomedicines10020345
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author Shmelev, Mikhail E.
Titov, Sergei I.
Belousov, Andrei S.
Farniev, Vladislav M.
Zhmenia, Valeriia M.
Lanskikh, Daria V.
Penkova, Alina O.
Kumeiko, Vadim V.
author_facet Shmelev, Mikhail E.
Titov, Sergei I.
Belousov, Andrei S.
Farniev, Vladislav M.
Zhmenia, Valeriia M.
Lanskikh, Daria V.
Penkova, Alina O.
Kumeiko, Vadim V.
author_sort Shmelev, Mikhail E.
collection PubMed
description Cell and tissue nanomechanics, being inspired by progress in high-resolution physical mapping, has recently burst into biomedical research, discovering not only new characteristics of normal and diseased tissues, but also unveiling previously unknown mechanisms of pathological processes. Some parallels can be drawn between early development and carcinogenesis. Early embryogenesis, up to the blastocyst stage, requires a soft microenvironment and internal mechanical signals induced by the contractility of the cortical actomyosin cytoskeleton, stimulating quick cell divisions. During further development from the blastocyst implantation to placenta formation, decidua stiffness is increased ten-fold when compared to non-pregnant endometrium. Organogenesis is mediated by mechanosignaling inspired by intercellular junction formation with the involvement of mechanotransduction from the extracellular matrix (ECM). Carcinogenesis dramatically changes the mechanical properties of cells and their microenvironment, generally reproducing the structural properties and molecular organization of embryonic tissues, but with a higher stiffness of the ECM and higher cellular softness and fluidity. These changes are associated with the complete rearrangement of the entire tissue skeleton involving the ECM, cytoskeleton, and the nuclear scaffold, all integrated with each other in a joint network. The important changes occur in the cancer stem-cell niche responsible for tumor promotion and metastatic growth. We expect that the promising concept based on the natural selection of cancer cells fixing the most invasive phenotypes and genotypes by reciprocal regulation through ECM-mediated nanomechanical feedback loop can be exploited to create new therapeutic strategies for cancer treatment.
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spelling pubmed-89617772022-03-30 Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis Shmelev, Mikhail E. Titov, Sergei I. Belousov, Andrei S. Farniev, Vladislav M. Zhmenia, Valeriia M. Lanskikh, Daria V. Penkova, Alina O. Kumeiko, Vadim V. Biomedicines Review Cell and tissue nanomechanics, being inspired by progress in high-resolution physical mapping, has recently burst into biomedical research, discovering not only new characteristics of normal and diseased tissues, but also unveiling previously unknown mechanisms of pathological processes. Some parallels can be drawn between early development and carcinogenesis. Early embryogenesis, up to the blastocyst stage, requires a soft microenvironment and internal mechanical signals induced by the contractility of the cortical actomyosin cytoskeleton, stimulating quick cell divisions. During further development from the blastocyst implantation to placenta formation, decidua stiffness is increased ten-fold when compared to non-pregnant endometrium. Organogenesis is mediated by mechanosignaling inspired by intercellular junction formation with the involvement of mechanotransduction from the extracellular matrix (ECM). Carcinogenesis dramatically changes the mechanical properties of cells and their microenvironment, generally reproducing the structural properties and molecular organization of embryonic tissues, but with a higher stiffness of the ECM and higher cellular softness and fluidity. These changes are associated with the complete rearrangement of the entire tissue skeleton involving the ECM, cytoskeleton, and the nuclear scaffold, all integrated with each other in a joint network. The important changes occur in the cancer stem-cell niche responsible for tumor promotion and metastatic growth. We expect that the promising concept based on the natural selection of cancer cells fixing the most invasive phenotypes and genotypes by reciprocal regulation through ECM-mediated nanomechanical feedback loop can be exploited to create new therapeutic strategies for cancer treatment. MDPI 2022-02-01 /pmc/articles/PMC8961777/ /pubmed/35203554 http://dx.doi.org/10.3390/biomedicines10020345 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shmelev, Mikhail E.
Titov, Sergei I.
Belousov, Andrei S.
Farniev, Vladislav M.
Zhmenia, Valeriia M.
Lanskikh, Daria V.
Penkova, Alina O.
Kumeiko, Vadim V.
Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis
title Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis
title_full Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis
title_fullStr Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis
title_full_unstemmed Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis
title_short Cell and Tissue Nanomechanics: From Early Development to Carcinogenesis
title_sort cell and tissue nanomechanics: from early development to carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961777/
https://www.ncbi.nlm.nih.gov/pubmed/35203554
http://dx.doi.org/10.3390/biomedicines10020345
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