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Human Milk Oligosaccharides: Potential Applications in COVID-19

Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a global health crisis with more than four million deaths worldwide. A substantial number of COVID-19 survivors continue suffering from long-COVID syndrome, a long-term comp...

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Detalles Bibliográficos
Autores principales: Chutipongtanate, Somchai, Morrow, Ardythe L., Newburg, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961778/
https://www.ncbi.nlm.nih.gov/pubmed/35203555
http://dx.doi.org/10.3390/biomedicines10020346
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author Chutipongtanate, Somchai
Morrow, Ardythe L.
Newburg, David S.
author_facet Chutipongtanate, Somchai
Morrow, Ardythe L.
Newburg, David S.
author_sort Chutipongtanate, Somchai
collection PubMed
description Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a global health crisis with more than four million deaths worldwide. A substantial number of COVID-19 survivors continue suffering from long-COVID syndrome, a long-term complication exhibiting chronic inflammation and gut dysbiosis. Much effort is being expended to improve therapeutic outcomes. Human milk oligosaccharides (hMOS) are non-digestible carbohydrates known to exert health benefits in breastfed infants by preventing infection, maintaining immune homeostasis and nurturing healthy gut microbiota. These beneficial effects suggest the hypothesis that hMOS might have applications in COVID-19 as receptor decoys, immunomodulators, mucosal signaling agents, and prebiotics. This review summarizes hMOS biogenesis and classification, describes the possible mechanisms of action of hMOS upon different phases of SARS-CoV-2 infection, and discusses the challenges and opportunities of hMOS research for clinical applications in COVID-19.
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spelling pubmed-89617782022-03-30 Human Milk Oligosaccharides: Potential Applications in COVID-19 Chutipongtanate, Somchai Morrow, Ardythe L. Newburg, David S. Biomedicines Review Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a global health crisis with more than four million deaths worldwide. A substantial number of COVID-19 survivors continue suffering from long-COVID syndrome, a long-term complication exhibiting chronic inflammation and gut dysbiosis. Much effort is being expended to improve therapeutic outcomes. Human milk oligosaccharides (hMOS) are non-digestible carbohydrates known to exert health benefits in breastfed infants by preventing infection, maintaining immune homeostasis and nurturing healthy gut microbiota. These beneficial effects suggest the hypothesis that hMOS might have applications in COVID-19 as receptor decoys, immunomodulators, mucosal signaling agents, and prebiotics. This review summarizes hMOS biogenesis and classification, describes the possible mechanisms of action of hMOS upon different phases of SARS-CoV-2 infection, and discusses the challenges and opportunities of hMOS research for clinical applications in COVID-19. MDPI 2022-02-01 /pmc/articles/PMC8961778/ /pubmed/35203555 http://dx.doi.org/10.3390/biomedicines10020346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chutipongtanate, Somchai
Morrow, Ardythe L.
Newburg, David S.
Human Milk Oligosaccharides: Potential Applications in COVID-19
title Human Milk Oligosaccharides: Potential Applications in COVID-19
title_full Human Milk Oligosaccharides: Potential Applications in COVID-19
title_fullStr Human Milk Oligosaccharides: Potential Applications in COVID-19
title_full_unstemmed Human Milk Oligosaccharides: Potential Applications in COVID-19
title_short Human Milk Oligosaccharides: Potential Applications in COVID-19
title_sort human milk oligosaccharides: potential applications in covid-19
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961778/
https://www.ncbi.nlm.nih.gov/pubmed/35203555
http://dx.doi.org/10.3390/biomedicines10020346
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