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Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases

Despite recent leaps in modern medicine, progress in the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of therapeutics into the brain, and the complexity of neurological processes, limits the specificity of potential therapeut...

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Autores principales: Yeo, Xin Yi, Cunliffe, Grace, Ho, Roger C., Lee, Su Seong, Jung, Sangyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961788/
https://www.ncbi.nlm.nih.gov/pubmed/35203552
http://dx.doi.org/10.3390/biomedicines10020343
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author Yeo, Xin Yi
Cunliffe, Grace
Ho, Roger C.
Lee, Su Seong
Jung, Sangyong
author_facet Yeo, Xin Yi
Cunliffe, Grace
Ho, Roger C.
Lee, Su Seong
Jung, Sangyong
author_sort Yeo, Xin Yi
collection PubMed
description Despite recent leaps in modern medicine, progress in the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of therapeutics into the brain, and the complexity of neurological processes, limits the specificity of potential therapeutics. Moreover, a lack of etiological understanding and the irreversible nature of neurological conditions have resulted in low tolerability and high failure rates towards existing small molecule-based treatments. Neuropeptides, which are small proteinaceous molecules produced by the body, either in the nervous system or the peripheral organs, modulate neurological function. Although peptide-based therapeutics originated from the treatment of metabolic diseases in the 1920s, the adoption and development of peptide drugs for neurological conditions are relatively recent. In this review, we examine the natural roles of neuropeptides in the modulation of neurological function and the development of neurological disorders. Furthermore, we highlight the potential of these proteinaceous molecules in filling gaps in current therapeutics.
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spelling pubmed-89617882022-03-30 Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases Yeo, Xin Yi Cunliffe, Grace Ho, Roger C. Lee, Su Seong Jung, Sangyong Biomedicines Review Despite recent leaps in modern medicine, progress in the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of therapeutics into the brain, and the complexity of neurological processes, limits the specificity of potential therapeutics. Moreover, a lack of etiological understanding and the irreversible nature of neurological conditions have resulted in low tolerability and high failure rates towards existing small molecule-based treatments. Neuropeptides, which are small proteinaceous molecules produced by the body, either in the nervous system or the peripheral organs, modulate neurological function. Although peptide-based therapeutics originated from the treatment of metabolic diseases in the 1920s, the adoption and development of peptide drugs for neurological conditions are relatively recent. In this review, we examine the natural roles of neuropeptides in the modulation of neurological function and the development of neurological disorders. Furthermore, we highlight the potential of these proteinaceous molecules in filling gaps in current therapeutics. MDPI 2022-02-01 /pmc/articles/PMC8961788/ /pubmed/35203552 http://dx.doi.org/10.3390/biomedicines10020343 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yeo, Xin Yi
Cunliffe, Grace
Ho, Roger C.
Lee, Su Seong
Jung, Sangyong
Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
title Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
title_full Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
title_fullStr Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
title_full_unstemmed Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
title_short Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
title_sort potentials of neuropeptides as therapeutic agents for neurological diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961788/
https://www.ncbi.nlm.nih.gov/pubmed/35203552
http://dx.doi.org/10.3390/biomedicines10020343
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