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Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases
Despite recent leaps in modern medicine, progress in the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of therapeutics into the brain, and the complexity of neurological processes, limits the specificity of potential therapeut...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961788/ https://www.ncbi.nlm.nih.gov/pubmed/35203552 http://dx.doi.org/10.3390/biomedicines10020343 |
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author | Yeo, Xin Yi Cunliffe, Grace Ho, Roger C. Lee, Su Seong Jung, Sangyong |
author_facet | Yeo, Xin Yi Cunliffe, Grace Ho, Roger C. Lee, Su Seong Jung, Sangyong |
author_sort | Yeo, Xin Yi |
collection | PubMed |
description | Despite recent leaps in modern medicine, progress in the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of therapeutics into the brain, and the complexity of neurological processes, limits the specificity of potential therapeutics. Moreover, a lack of etiological understanding and the irreversible nature of neurological conditions have resulted in low tolerability and high failure rates towards existing small molecule-based treatments. Neuropeptides, which are small proteinaceous molecules produced by the body, either in the nervous system or the peripheral organs, modulate neurological function. Although peptide-based therapeutics originated from the treatment of metabolic diseases in the 1920s, the adoption and development of peptide drugs for neurological conditions are relatively recent. In this review, we examine the natural roles of neuropeptides in the modulation of neurological function and the development of neurological disorders. Furthermore, we highlight the potential of these proteinaceous molecules in filling gaps in current therapeutics. |
format | Online Article Text |
id | pubmed-8961788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89617882022-03-30 Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases Yeo, Xin Yi Cunliffe, Grace Ho, Roger C. Lee, Su Seong Jung, Sangyong Biomedicines Review Despite recent leaps in modern medicine, progress in the treatment of neurological diseases remains slow. The near impermeable blood-brain barrier (BBB) that prevents the entry of therapeutics into the brain, and the complexity of neurological processes, limits the specificity of potential therapeutics. Moreover, a lack of etiological understanding and the irreversible nature of neurological conditions have resulted in low tolerability and high failure rates towards existing small molecule-based treatments. Neuropeptides, which are small proteinaceous molecules produced by the body, either in the nervous system or the peripheral organs, modulate neurological function. Although peptide-based therapeutics originated from the treatment of metabolic diseases in the 1920s, the adoption and development of peptide drugs for neurological conditions are relatively recent. In this review, we examine the natural roles of neuropeptides in the modulation of neurological function and the development of neurological disorders. Furthermore, we highlight the potential of these proteinaceous molecules in filling gaps in current therapeutics. MDPI 2022-02-01 /pmc/articles/PMC8961788/ /pubmed/35203552 http://dx.doi.org/10.3390/biomedicines10020343 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yeo, Xin Yi Cunliffe, Grace Ho, Roger C. Lee, Su Seong Jung, Sangyong Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases |
title | Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases |
title_full | Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases |
title_fullStr | Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases |
title_full_unstemmed | Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases |
title_short | Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases |
title_sort | potentials of neuropeptides as therapeutic agents for neurological diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961788/ https://www.ncbi.nlm.nih.gov/pubmed/35203552 http://dx.doi.org/10.3390/biomedicines10020343 |
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