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The Paracaspase MALT1 in Cancer
Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961791/ https://www.ncbi.nlm.nih.gov/pubmed/35203553 http://dx.doi.org/10.3390/biomedicines10020344 |
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author | Gomez Solsona, Beatriz Schmitt, Anja Schulze-Osthoff, Klaus Hailfinger, Stephan |
author_facet | Gomez Solsona, Beatriz Schmitt, Anja Schulze-Osthoff, Klaus Hailfinger, Stephan |
author_sort | Gomez Solsona, Beatriz |
collection | PubMed |
description | Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In various hematological malignancies and solid tumors, MALT1 is constitutively activated and drives chronic NF-κB target gene expression. Deregulated MALT1 activity in cancer thus promotes tumor cell survival, proliferation, and metastasis. Since the molecular function of MALT1 partially requires its protease activity, pharmacological targeting of MALT1 may represent a promising anti-cancer strategy. Here, we review the molecular features of MALT1 activation and function as well as the therapeutic potential of MALT1 inhibition in hematological malignancies and solid tumors. |
format | Online Article Text |
id | pubmed-8961791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89617912022-03-30 The Paracaspase MALT1 in Cancer Gomez Solsona, Beatriz Schmitt, Anja Schulze-Osthoff, Klaus Hailfinger, Stephan Biomedicines Review Almost twenty years ago, the importance of the paracaspase MALT1 in antigen receptor-induced NF-κB activation was first described. Since then, several other immune receptors, G-protein-coupled receptors, and receptor tyrosine kinases were identified as relying on MALT1 to induce NF-κB activation. In various hematological malignancies and solid tumors, MALT1 is constitutively activated and drives chronic NF-κB target gene expression. Deregulated MALT1 activity in cancer thus promotes tumor cell survival, proliferation, and metastasis. Since the molecular function of MALT1 partially requires its protease activity, pharmacological targeting of MALT1 may represent a promising anti-cancer strategy. Here, we review the molecular features of MALT1 activation and function as well as the therapeutic potential of MALT1 inhibition in hematological malignancies and solid tumors. MDPI 2022-02-01 /pmc/articles/PMC8961791/ /pubmed/35203553 http://dx.doi.org/10.3390/biomedicines10020344 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gomez Solsona, Beatriz Schmitt, Anja Schulze-Osthoff, Klaus Hailfinger, Stephan The Paracaspase MALT1 in Cancer |
title | The Paracaspase MALT1 in Cancer |
title_full | The Paracaspase MALT1 in Cancer |
title_fullStr | The Paracaspase MALT1 in Cancer |
title_full_unstemmed | The Paracaspase MALT1 in Cancer |
title_short | The Paracaspase MALT1 in Cancer |
title_sort | paracaspase malt1 in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961791/ https://www.ncbi.nlm.nih.gov/pubmed/35203553 http://dx.doi.org/10.3390/biomedicines10020344 |
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