Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia

Hereditary spastic paraplegias (HSPs) are a group of inherited, progressive neurodegenerative conditions characterised by prominent lower-limb spasticity and weakness, caused by a length-dependent degeneration of the longest corticospinal upper motor neurons. While more than 80 spastic paraplegia ge...

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Detalles Bibliográficos
Autores principales: Byrne, Dwayne J., Garcia-Pardo, M. Elena, Cole, Nelson B., Batnasan, Belguun, Heneghan, Sophia, Sohail, Anood, Blackstone, Craig, O’Sullivan, Niamh C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961908/
https://www.ncbi.nlm.nih.gov/pubmed/35346366
http://dx.doi.org/10.1186/s40478-022-01343-6

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