Cargando…

Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice

Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. According to the “inoculation of stress” hypothesis, a brief period of maternal separation (MS) can provide protection ag...

Descripción completa

Detalles Bibliográficos
Autores principales: Calpe-López, C., Martínez-Caballero, M. A., García-Pardo, M. P., Aguilar, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961977/
https://www.ncbi.nlm.nih.gov/pubmed/35359840
http://dx.doi.org/10.3389/fphar.2022.825522
_version_ 1784677702509264896
author Calpe-López, C.
Martínez-Caballero, M. A.
García-Pardo, M. P.
Aguilar, M. A.
author_facet Calpe-López, C.
Martínez-Caballero, M. A.
García-Pardo, M. P.
Aguilar, M. A.
author_sort Calpe-López, C.
collection PubMed
description Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. According to the “inoculation of stress” hypothesis, a brief period of maternal separation (MS) can provide protection against the negative effects of IRSD. The aim of the present study was to assess whether exposure to a brief episode of MS prevents the subsequent short-term effects of IRSD on depression- and anxiety-like behaviors and to explore its long-term effects on cocaine CPP in mice. Four groups of male C57BL/6 mice were employed; two groups were separated from their mother [6 h on postnatal day (PND) 9], while the other two groups were not (controls). On PND 47, 50, 53 and 56, mice that had experienced MS were exposed to social defeat in the cage of an aggressive resident mouse (MS + IRSD group) or were allowed to explore an empty cage (MS + EXPL group). The same procedure was performed with control mice that had not experienced MS (CONTROL + IRSD and CONTROL + EXPL groups). On PND57-58, all the mice performed the elevated plus maze and the hole-board, social interaction and splash tests. Three weeks after the last episode of defeat, all the mice underwent the CPP procedure with cocaine (1 mg/kg). Irrespective of whether or not MS had taken place, a reduction in open arms measures, dips, and social interaction was observed in mice that experienced IRSD. A higher latency of grooming and acquisition of cocaine-induced CPP were observed only in mice exposed to IRSD alone (CONTROL + IRSD). These results suggest that exposure to a brief episode of stress early in life increases the subsequent resilience of animals to the effects of social stress on vulnerability to cocaine.
format Online
Article
Text
id pubmed-8961977
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89619772022-03-30 Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice Calpe-López, C. Martínez-Caballero, M. A. García-Pardo, M. P. Aguilar, M. A. Front Pharmacol Pharmacology Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. According to the “inoculation of stress” hypothesis, a brief period of maternal separation (MS) can provide protection against the negative effects of IRSD. The aim of the present study was to assess whether exposure to a brief episode of MS prevents the subsequent short-term effects of IRSD on depression- and anxiety-like behaviors and to explore its long-term effects on cocaine CPP in mice. Four groups of male C57BL/6 mice were employed; two groups were separated from their mother [6 h on postnatal day (PND) 9], while the other two groups were not (controls). On PND 47, 50, 53 and 56, mice that had experienced MS were exposed to social defeat in the cage of an aggressive resident mouse (MS + IRSD group) or were allowed to explore an empty cage (MS + EXPL group). The same procedure was performed with control mice that had not experienced MS (CONTROL + IRSD and CONTROL + EXPL groups). On PND57-58, all the mice performed the elevated plus maze and the hole-board, social interaction and splash tests. Three weeks after the last episode of defeat, all the mice underwent the CPP procedure with cocaine (1 mg/kg). Irrespective of whether or not MS had taken place, a reduction in open arms measures, dips, and social interaction was observed in mice that experienced IRSD. A higher latency of grooming and acquisition of cocaine-induced CPP were observed only in mice exposed to IRSD alone (CONTROL + IRSD). These results suggest that exposure to a brief episode of stress early in life increases the subsequent resilience of animals to the effects of social stress on vulnerability to cocaine. Frontiers Media S.A. 2022-03-11 /pmc/articles/PMC8961977/ /pubmed/35359840 http://dx.doi.org/10.3389/fphar.2022.825522 Text en Copyright © 2022 Calpe-López, Martínez-Caballero, García-Pardo and Aguilar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Calpe-López, C.
Martínez-Caballero, M. A.
García-Pardo, M. P.
Aguilar, M. A.
Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice
title Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice
title_full Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice
title_fullStr Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice
title_full_unstemmed Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice
title_short Brief Maternal Separation Inoculates Against the Effects of Social Stress on Depression-Like Behavior and Cocaine Reward in Mice
title_sort brief maternal separation inoculates against the effects of social stress on depression-like behavior and cocaine reward in mice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961977/
https://www.ncbi.nlm.nih.gov/pubmed/35359840
http://dx.doi.org/10.3389/fphar.2022.825522
work_keys_str_mv AT calpelopezc briefmaternalseparationinoculatesagainsttheeffectsofsocialstressondepressionlikebehaviorandcocainerewardinmice
AT martinezcaballeroma briefmaternalseparationinoculatesagainsttheeffectsofsocialstressondepressionlikebehaviorandcocainerewardinmice
AT garciapardomp briefmaternalseparationinoculatesagainsttheeffectsofsocialstressondepressionlikebehaviorandcocainerewardinmice
AT aguilarma briefmaternalseparationinoculatesagainsttheeffectsofsocialstressondepressionlikebehaviorandcocainerewardinmice