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Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction

PURPOSE: To evaluate the efficacy of single intravitreal injection of an expansile concentration of sulphur hexafluoride gas (SF6) in treating patients with symptomatic focal vitreomacular traction (VMT) documented by spectral domain optical coherence tomography (SD-OCT) preoperatively. METHODS: Thi...

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Autores principales: Fouad, Ahmed N., Eissa, Iman M., Nassar, Ghada A., Leila, Mahmoud, Fathy, Adel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962114/
https://www.ncbi.nlm.nih.gov/pubmed/35346391
http://dx.doi.org/10.1186/s40942-022-00376-2
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author Fouad, Ahmed N.
Eissa, Iman M.
Nassar, Ghada A.
Leila, Mahmoud
Fathy, Adel M.
author_facet Fouad, Ahmed N.
Eissa, Iman M.
Nassar, Ghada A.
Leila, Mahmoud
Fathy, Adel M.
author_sort Fouad, Ahmed N.
collection PubMed
description PURPOSE: To evaluate the efficacy of single intravitreal injection of an expansile concentration of sulphur hexafluoride gas (SF6) in treating patients with symptomatic focal vitreomacular traction (VMT) documented by spectral domain optical coherence tomography (SD-OCT) preoperatively. METHODS: This is a prospective interventional case series including 30 eyes of 29 patients with symptomatic focal VMT evident on SD-OCT. Pre-operatively, mean best corrected visual acuity (BCVA) was 20/125 (range 20/400–20/40). Mean central foveal thickness (CFT) was 382 μm (range 149–576 μm; SD ± 91.88). All eyes received single intravitreal injection of 0.3 mL of 100% SF6 gas. Postoperatively, we performed SD-OCT at one week, one month, and three months for all eyes. Primary outcome measure was release of VMT. Secondary outcome measures were changes in postoperative BCVA andCFT. RESULTS: Overall, VMT release occurred in 24 of 30 eyes by the final follow-up visit (80% final release rate); furthermore, 76.9% of eyes with diabetic maculopathy and 25% of eyes with concurrent epiretinal membrane (ERM) had successful VMT release. VMT release was documented on SD-OCT at an average of 3 weeks (range, 1–12 weeks). The rate of release in phakic eyes was 90% (18 of 20 eyes) versus 60% in pseudophakic eyes (6 of 10 eyes). One patient developed a retinal break at upper nasal retina after two weeks of injection. CONCLUSION: Pneumatic vitreolysis (PVL) with limited face-down position is a viable option for treating focal VMT with few adverse events. Further studies are needed to evaluate its indications, benefits, and risks.
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spelling pubmed-89621142022-03-30 Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction Fouad, Ahmed N. Eissa, Iman M. Nassar, Ghada A. Leila, Mahmoud Fathy, Adel M. Int J Retina Vitreous Original Article PURPOSE: To evaluate the efficacy of single intravitreal injection of an expansile concentration of sulphur hexafluoride gas (SF6) in treating patients with symptomatic focal vitreomacular traction (VMT) documented by spectral domain optical coherence tomography (SD-OCT) preoperatively. METHODS: This is a prospective interventional case series including 30 eyes of 29 patients with symptomatic focal VMT evident on SD-OCT. Pre-operatively, mean best corrected visual acuity (BCVA) was 20/125 (range 20/400–20/40). Mean central foveal thickness (CFT) was 382 μm (range 149–576 μm; SD ± 91.88). All eyes received single intravitreal injection of 0.3 mL of 100% SF6 gas. Postoperatively, we performed SD-OCT at one week, one month, and three months for all eyes. Primary outcome measure was release of VMT. Secondary outcome measures were changes in postoperative BCVA andCFT. RESULTS: Overall, VMT release occurred in 24 of 30 eyes by the final follow-up visit (80% final release rate); furthermore, 76.9% of eyes with diabetic maculopathy and 25% of eyes with concurrent epiretinal membrane (ERM) had successful VMT release. VMT release was documented on SD-OCT at an average of 3 weeks (range, 1–12 weeks). The rate of release in phakic eyes was 90% (18 of 20 eyes) versus 60% in pseudophakic eyes (6 of 10 eyes). One patient developed a retinal break at upper nasal retina after two weeks of injection. CONCLUSION: Pneumatic vitreolysis (PVL) with limited face-down position is a viable option for treating focal VMT with few adverse events. Further studies are needed to evaluate its indications, benefits, and risks. BioMed Central 2022-03-28 /pmc/articles/PMC8962114/ /pubmed/35346391 http://dx.doi.org/10.1186/s40942-022-00376-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Original Article
Fouad, Ahmed N.
Eissa, Iman M.
Nassar, Ghada A.
Leila, Mahmoud
Fathy, Adel M.
Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction
title Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction
title_full Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction
title_fullStr Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction
title_full_unstemmed Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction
title_short Effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction
title_sort effect of pneumatic vitreolysis in management of patients with symptomatic focal vitreomacular traction
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962114/
https://www.ncbi.nlm.nih.gov/pubmed/35346391
http://dx.doi.org/10.1186/s40942-022-00376-2
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