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Listeriosis during pregnancy: a retrospective cohort study

BACKGROUND: Pregnancy-associated listeriosis is a severe infectious disease and potentially leads to fetal/neonatal fatal, while limited information on pregnancy-associated listeriosis is available in China. This study aimed to reveal the clinical characteristics and outcomes of pregnancy-associated...

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Autores principales: Ke, Yefang, Ye, Lina, Zhu, Pan, Sun, Ying, Zhu, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962181/
https://www.ncbi.nlm.nih.gov/pubmed/35346105
http://dx.doi.org/10.1186/s12884-022-04613-2
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author Ke, Yefang
Ye, Lina
Zhu, Pan
Sun, Ying
Zhu, Zhe
author_facet Ke, Yefang
Ye, Lina
Zhu, Pan
Sun, Ying
Zhu, Zhe
author_sort Ke, Yefang
collection PubMed
description BACKGROUND: Pregnancy-associated listeriosis is a severe infectious disease and potentially leads to fetal/neonatal fatal, while limited information on pregnancy-associated listeriosis is available in China. This study aimed to reveal the clinical characteristics and outcomes of pregnancy-associated listeriosis cases and provide references for treating and managing this disease. METHODS: We performed a retrospective study on maternal and neonatal patients with pregnancy-associated listeriosis. The clinical characteristics of pregnancy-associated listeriosis were studied, and the outcome determinants of neonatal listeriosis were explored. RESULTS: 14 cases of pregnancy-associated listeriosis were identified. The incidence of pregnancy-associated listeriosis in our hospital was 16.69/100,000 births. All of the 14 maternal patients eventually recovered after delivery shortly with no sequelae. None of the 12 mothers who delivered in this hospital received antepartum first-line empirical treatment. Among the 14 neonatal cases, 1 was late-onset listeriosis and 13 were early-onset cases; 11 survived and 3 died. Fatality rates were significantly higher in outborn neonates (P = 0.005). Besides, higher mortality rates were observed in neonates with lower birth weight (P = 0.038), gestational age < 28 weeks (P = 0.056), and Apgar score (5(th) min) < 5 (P = 0.056), with marginally significant differences. CONCLUSIONS: Pregnancy-associated listeriosis would bring disastrous effects to the neonatal cases, especially to the outborn, low birth weight, and low gestational age of neonates. Timely detection and treatment should be taken seriously for the key neonates. How to early detect L. monocytogenes infected cases, especially in the prenatal stage, remains a serious challenge.
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spelling pubmed-89621812022-03-30 Listeriosis during pregnancy: a retrospective cohort study Ke, Yefang Ye, Lina Zhu, Pan Sun, Ying Zhu, Zhe BMC Pregnancy Childbirth Research BACKGROUND: Pregnancy-associated listeriosis is a severe infectious disease and potentially leads to fetal/neonatal fatal, while limited information on pregnancy-associated listeriosis is available in China. This study aimed to reveal the clinical characteristics and outcomes of pregnancy-associated listeriosis cases and provide references for treating and managing this disease. METHODS: We performed a retrospective study on maternal and neonatal patients with pregnancy-associated listeriosis. The clinical characteristics of pregnancy-associated listeriosis were studied, and the outcome determinants of neonatal listeriosis were explored. RESULTS: 14 cases of pregnancy-associated listeriosis were identified. The incidence of pregnancy-associated listeriosis in our hospital was 16.69/100,000 births. All of the 14 maternal patients eventually recovered after delivery shortly with no sequelae. None of the 12 mothers who delivered in this hospital received antepartum first-line empirical treatment. Among the 14 neonatal cases, 1 was late-onset listeriosis and 13 were early-onset cases; 11 survived and 3 died. Fatality rates were significantly higher in outborn neonates (P = 0.005). Besides, higher mortality rates were observed in neonates with lower birth weight (P = 0.038), gestational age < 28 weeks (P = 0.056), and Apgar score (5(th) min) < 5 (P = 0.056), with marginally significant differences. CONCLUSIONS: Pregnancy-associated listeriosis would bring disastrous effects to the neonatal cases, especially to the outborn, low birth weight, and low gestational age of neonates. Timely detection and treatment should be taken seriously for the key neonates. How to early detect L. monocytogenes infected cases, especially in the prenatal stage, remains a serious challenge. BioMed Central 2022-03-28 /pmc/articles/PMC8962181/ /pubmed/35346105 http://dx.doi.org/10.1186/s12884-022-04613-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Ke, Yefang
Ye, Lina
Zhu, Pan
Sun, Ying
Zhu, Zhe
Listeriosis during pregnancy: a retrospective cohort study
title Listeriosis during pregnancy: a retrospective cohort study
title_full Listeriosis during pregnancy: a retrospective cohort study
title_fullStr Listeriosis during pregnancy: a retrospective cohort study
title_full_unstemmed Listeriosis during pregnancy: a retrospective cohort study
title_short Listeriosis during pregnancy: a retrospective cohort study
title_sort listeriosis during pregnancy: a retrospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962181/
https://www.ncbi.nlm.nih.gov/pubmed/35346105
http://dx.doi.org/10.1186/s12884-022-04613-2
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