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Multimodal ocular imaging of known and novel corneal stromal disorders in dogs

BACKGROUND: Imaging features obtained with Fourier-domain optical coherence tomography (FD-OCT) and in vivo confocal microscopy (IVCM) for corneal stromal disorders have been sparsely reported in dogs. This case report is a compilation of imaging features for three cases of different stromal disorde...

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Autores principales: Park, Sangwan, Sebbag, Lionel, Moore, Bret A., Casanova, M. Isabel, Leonard, Brian C., Daley, Nicole L., Steele, Kirsten A., Li, Jennifer Y., Murphy, Christopher J., Thomasy, Sara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962188/
https://www.ncbi.nlm.nih.gov/pubmed/35346188
http://dx.doi.org/10.1186/s12917-022-03214-7
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author Park, Sangwan
Sebbag, Lionel
Moore, Bret A.
Casanova, M. Isabel
Leonard, Brian C.
Daley, Nicole L.
Steele, Kirsten A.
Li, Jennifer Y.
Murphy, Christopher J.
Thomasy, Sara M.
author_facet Park, Sangwan
Sebbag, Lionel
Moore, Bret A.
Casanova, M. Isabel
Leonard, Brian C.
Daley, Nicole L.
Steele, Kirsten A.
Li, Jennifer Y.
Murphy, Christopher J.
Thomasy, Sara M.
author_sort Park, Sangwan
collection PubMed
description BACKGROUND: Imaging features obtained with Fourier-domain optical coherence tomography (FD-OCT) and in vivo confocal microscopy (IVCM) for corneal stromal disorders have been sparsely reported in dogs. This case report is a compilation of imaging features for three cases of different stromal disorders of the canine cornea which have not yet been reported elsewhere. CASE PRESENTATION: Lipid deposition in case 1 appeared as needle-shaped hyperreflective lines along the collagen lamellae, which correlated histologically with lipid clefts. In case 2, glycosaminoglycan accumulation by mucopolysaccharidosis type 1 caused diffuse stromal hyperreflectivity and depletion of keratocytes on IVCM and was associated with secondary corneal degeneration presumed to be calcium deposition. In case 3, posterior corneal stromal opacities in the absence of ocular inflammation were identified. Hyperreflective particles were scattered in the middle and posterior corneal stroma on FD-OCT. With IVCM, hyperreflective deposits were identified within keratocytes and the number of enlarged keratocytes containing hyperreflective deposits increased towards the posterior stroma. The bilateral, non-inflammatory nature and unique appearance with IVCM is most consistent with a posterior stromal dystrophy reminiscent of pre-Descemet corneal dystrophy described in humans. CONCLUSIONS: In vivo multimodal corneal imaging facilitated instantaneous microstructural analysis and may be valuable in the differential diagnosis of corneal stromal disorders in veterinary clinical practice. The non-specific nature of imaging findings occurs in some conditions such as mucopolysaccharidosis, thus in vivo corneal imaging should be complemented with other gold standard methods of definitive diagnosis.
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spelling pubmed-89621882022-03-30 Multimodal ocular imaging of known and novel corneal stromal disorders in dogs Park, Sangwan Sebbag, Lionel Moore, Bret A. Casanova, M. Isabel Leonard, Brian C. Daley, Nicole L. Steele, Kirsten A. Li, Jennifer Y. Murphy, Christopher J. Thomasy, Sara M. BMC Vet Res Case Report BACKGROUND: Imaging features obtained with Fourier-domain optical coherence tomography (FD-OCT) and in vivo confocal microscopy (IVCM) for corneal stromal disorders have been sparsely reported in dogs. This case report is a compilation of imaging features for three cases of different stromal disorders of the canine cornea which have not yet been reported elsewhere. CASE PRESENTATION: Lipid deposition in case 1 appeared as needle-shaped hyperreflective lines along the collagen lamellae, which correlated histologically with lipid clefts. In case 2, glycosaminoglycan accumulation by mucopolysaccharidosis type 1 caused diffuse stromal hyperreflectivity and depletion of keratocytes on IVCM and was associated with secondary corneal degeneration presumed to be calcium deposition. In case 3, posterior corneal stromal opacities in the absence of ocular inflammation were identified. Hyperreflective particles were scattered in the middle and posterior corneal stroma on FD-OCT. With IVCM, hyperreflective deposits were identified within keratocytes and the number of enlarged keratocytes containing hyperreflective deposits increased towards the posterior stroma. The bilateral, non-inflammatory nature and unique appearance with IVCM is most consistent with a posterior stromal dystrophy reminiscent of pre-Descemet corneal dystrophy described in humans. CONCLUSIONS: In vivo multimodal corneal imaging facilitated instantaneous microstructural analysis and may be valuable in the differential diagnosis of corneal stromal disorders in veterinary clinical practice. The non-specific nature of imaging findings occurs in some conditions such as mucopolysaccharidosis, thus in vivo corneal imaging should be complemented with other gold standard methods of definitive diagnosis. BioMed Central 2022-03-26 /pmc/articles/PMC8962188/ /pubmed/35346188 http://dx.doi.org/10.1186/s12917-022-03214-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Park, Sangwan
Sebbag, Lionel
Moore, Bret A.
Casanova, M. Isabel
Leonard, Brian C.
Daley, Nicole L.
Steele, Kirsten A.
Li, Jennifer Y.
Murphy, Christopher J.
Thomasy, Sara M.
Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
title Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
title_full Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
title_fullStr Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
title_full_unstemmed Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
title_short Multimodal ocular imaging of known and novel corneal stromal disorders in dogs
title_sort multimodal ocular imaging of known and novel corneal stromal disorders in dogs
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962188/
https://www.ncbi.nlm.nih.gov/pubmed/35346188
http://dx.doi.org/10.1186/s12917-022-03214-7
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