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Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors

Taste memory involves storing information through plasticity changes in the neural network of taste, including the insular cortex (IC) and ventral tegmental area (VTA), a critical provider of dopamine. Although a VTA-IC dopaminergic pathway has been demonstrated, its role to consolidate taste recogn...

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Autores principales: Gil-Lievana, Elvi, Ramírez-Mejía, Gerardo, Urrego-Morales, Oscar, Luis-Islas, Jorge, Gutierrez, Ranier, Bermúdez-Rattoni, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962201/
https://www.ncbi.nlm.nih.gov/pubmed/35360496
http://dx.doi.org/10.3389/fncel.2022.823220
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author Gil-Lievana, Elvi
Ramírez-Mejía, Gerardo
Urrego-Morales, Oscar
Luis-Islas, Jorge
Gutierrez, Ranier
Bermúdez-Rattoni, Federico
author_facet Gil-Lievana, Elvi
Ramírez-Mejía, Gerardo
Urrego-Morales, Oscar
Luis-Islas, Jorge
Gutierrez, Ranier
Bermúdez-Rattoni, Federico
author_sort Gil-Lievana, Elvi
collection PubMed
description Taste memory involves storing information through plasticity changes in the neural network of taste, including the insular cortex (IC) and ventral tegmental area (VTA), a critical provider of dopamine. Although a VTA-IC dopaminergic pathway has been demonstrated, its role to consolidate taste recognition memory remains poorly understood. We found that photostimulation of dopaminergic neurons in the VTA or VTA-IC dopaminergic terminals of TH-Cre mice improves the salience to consolidate a subthreshold novel taste stimulus regardless of its hedonic value, without altering their taste palatability. Importantly, the inhibition of the D1-like receptor into the IC impairs the salience to facilitate consolidation of an aversive taste recognition memory. Finally, our results showed that VTA photostimulation improves the salience to consolidate a conditioned taste aversion memory through the D1-like receptor into the IC. It is concluded that the dopamine activity from the VTA into IC is required to increase the salience enabling the consolidation of a taste recognition memory. Notably, the D1-like receptor activity into the IC is required to consolidate both innate and learned aversive taste memories but not appetitive taste memory.
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spelling pubmed-89622012022-03-30 Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors Gil-Lievana, Elvi Ramírez-Mejía, Gerardo Urrego-Morales, Oscar Luis-Islas, Jorge Gutierrez, Ranier Bermúdez-Rattoni, Federico Front Cell Neurosci Cellular Neuroscience Taste memory involves storing information through plasticity changes in the neural network of taste, including the insular cortex (IC) and ventral tegmental area (VTA), a critical provider of dopamine. Although a VTA-IC dopaminergic pathway has been demonstrated, its role to consolidate taste recognition memory remains poorly understood. We found that photostimulation of dopaminergic neurons in the VTA or VTA-IC dopaminergic terminals of TH-Cre mice improves the salience to consolidate a subthreshold novel taste stimulus regardless of its hedonic value, without altering their taste palatability. Importantly, the inhibition of the D1-like receptor into the IC impairs the salience to facilitate consolidation of an aversive taste recognition memory. Finally, our results showed that VTA photostimulation improves the salience to consolidate a conditioned taste aversion memory through the D1-like receptor into the IC. It is concluded that the dopamine activity from the VTA into IC is required to increase the salience enabling the consolidation of a taste recognition memory. Notably, the D1-like receptor activity into the IC is required to consolidate both innate and learned aversive taste memories but not appetitive taste memory. Frontiers Media S.A. 2022-03-11 /pmc/articles/PMC8962201/ /pubmed/35360496 http://dx.doi.org/10.3389/fncel.2022.823220 Text en Copyright © 2022 Gil-Lievana, Ramírez-Mejía, Urrego-Morales, Luis-Islas, Gutierrez and Bermúdez-Rattoni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Gil-Lievana, Elvi
Ramírez-Mejía, Gerardo
Urrego-Morales, Oscar
Luis-Islas, Jorge
Gutierrez, Ranier
Bermúdez-Rattoni, Federico
Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors
title Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors
title_full Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors
title_fullStr Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors
title_full_unstemmed Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors
title_short Photostimulation of Ventral Tegmental Area-Insular Cortex Dopaminergic Inputs Enhances the Salience to Consolidate Aversive Taste Recognition Memory via D1-Like Receptors
title_sort photostimulation of ventral tegmental area-insular cortex dopaminergic inputs enhances the salience to consolidate aversive taste recognition memory via d1-like receptors
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962201/
https://www.ncbi.nlm.nih.gov/pubmed/35360496
http://dx.doi.org/10.3389/fncel.2022.823220
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