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Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) survival is mainly reported at the time of treatment. Conditional survival is another prognostic tool to evaluate ESCC patients who has survived more than one year since treatment. METHODS: We analyzed data from 705 ESCC patients who underwent mi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962239/ https://www.ncbi.nlm.nih.gov/pubmed/35346110 http://dx.doi.org/10.1186/s12885-022-09423-5 |
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author | Liang, Mingqiang Xiao, Jiazhou Chen, Maohui Zheng, Bin Chen, Chun |
author_facet | Liang, Mingqiang Xiao, Jiazhou Chen, Maohui Zheng, Bin Chen, Chun |
author_sort | Liang, Mingqiang |
collection | PubMed |
description | BACKGROUND: Esophageal squamous cell carcinoma (ESCC) survival is mainly reported at the time of treatment. Conditional survival is another prognostic tool to evaluate ESCC patients who has survived more than one year since treatment. METHODS: We analyzed data from 705 ESCC patients who underwent minimally invasive surgery between 2013 and 2016. Using the Kaplan–Meier method, we computed a 5-year relative conditional survival. We also investigated the prognostic factors associated with survival using Cox proportional hazards models. RESULTS: Conditional survival improved over time for all cohorts of ESCC patients who survived a period after surgery. The greatest improve in conditional survival were observed in patients 2 years after surgery. In addition, the results of the Cox survival model from the time of surgery, T stage (p < 0.001), N stage (p < 0.001), and anastomotic leak (p = 0.022), were significantly associated with survival. However, the results of the Cox survival model from 2 years after surgery, N stage (p < 0.001), and anastomotic leak (p = 0.032) were significantly associated with survival. CONCLUSION: For ESCC patients who survived a period after surgery, the largest increases in conditional survival were observed in patients 2 years after surgery. We suggest that patients with anastomotic leakage and higher T and N stages should be strictly screened according to various time, and that conditional survival should be used as a powerful prognostic tool for ESCC patients. |
format | Online Article Text |
id | pubmed-8962239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89622392022-03-30 Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery Liang, Mingqiang Xiao, Jiazhou Chen, Maohui Zheng, Bin Chen, Chun BMC Cancer Research Article BACKGROUND: Esophageal squamous cell carcinoma (ESCC) survival is mainly reported at the time of treatment. Conditional survival is another prognostic tool to evaluate ESCC patients who has survived more than one year since treatment. METHODS: We analyzed data from 705 ESCC patients who underwent minimally invasive surgery between 2013 and 2016. Using the Kaplan–Meier method, we computed a 5-year relative conditional survival. We also investigated the prognostic factors associated with survival using Cox proportional hazards models. RESULTS: Conditional survival improved over time for all cohorts of ESCC patients who survived a period after surgery. The greatest improve in conditional survival were observed in patients 2 years after surgery. In addition, the results of the Cox survival model from the time of surgery, T stage (p < 0.001), N stage (p < 0.001), and anastomotic leak (p = 0.022), were significantly associated with survival. However, the results of the Cox survival model from 2 years after surgery, N stage (p < 0.001), and anastomotic leak (p = 0.032) were significantly associated with survival. CONCLUSION: For ESCC patients who survived a period after surgery, the largest increases in conditional survival were observed in patients 2 years after surgery. We suggest that patients with anastomotic leakage and higher T and N stages should be strictly screened according to various time, and that conditional survival should be used as a powerful prognostic tool for ESCC patients. BioMed Central 2022-03-26 /pmc/articles/PMC8962239/ /pubmed/35346110 http://dx.doi.org/10.1186/s12885-022-09423-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Liang, Mingqiang Xiao, Jiazhou Chen, Maohui Zheng, Bin Chen, Chun Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery |
title | Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery |
title_full | Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery |
title_fullStr | Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery |
title_full_unstemmed | Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery |
title_short | Prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery |
title_sort | prognostic variables for conditional survival in patients with esophageal squamous cell carcinoma who underwent minimally invasive surgery |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962239/ https://www.ncbi.nlm.nih.gov/pubmed/35346110 http://dx.doi.org/10.1186/s12885-022-09423-5 |
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