The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived...

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Autores principales: Kussainova, Assiya, Bulgakova, Olga, Aripova, Akmaral, Khalid, Zumama, Bersimbaev, Rakhmetkazhi, Izzotti, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962319/
https://www.ncbi.nlm.nih.gov/pubmed/35203638
http://dx.doi.org/10.3390/biomedicines10020428
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author Kussainova, Assiya
Bulgakova, Olga
Aripova, Akmaral
Khalid, Zumama
Bersimbaev, Rakhmetkazhi
Izzotti, Alberto
author_facet Kussainova, Assiya
Bulgakova, Olga
Aripova, Akmaral
Khalid, Zumama
Bersimbaev, Rakhmetkazhi
Izzotti, Alberto
author_sort Kussainova, Assiya
collection PubMed
description MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure.
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spelling pubmed-89623192022-03-30 The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer Kussainova, Assiya Bulgakova, Olga Aripova, Akmaral Khalid, Zumama Bersimbaev, Rakhmetkazhi Izzotti, Alberto Biomedicines Review MicroRNAs are short, non-coding RNA molecules regulating gene expression by inhibiting the translation of messenger RNA (mRNA) or leading to degradation. The miRNAs are encoded in the nuclear genome and exported to the cytosol. However, miRNAs have been found in mitochondria and are probably derived from mitochondrial DNA. These miRNAs are able to directly regulate mitochondrial genes and mitochondrial activity. Mitochondrial dysfunction is the cause of many diseases, including cancer. In this review, we consider the role of mitochondrial miRNAs in the pathogenesis of lung cancer with particular reference to radon exposure. MDPI 2022-02-11 /pmc/articles/PMC8962319/ /pubmed/35203638 http://dx.doi.org/10.3390/biomedicines10020428 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kussainova, Assiya
Bulgakova, Olga
Aripova, Akmaral
Khalid, Zumama
Bersimbaev, Rakhmetkazhi
Izzotti, Alberto
The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
title The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
title_full The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
title_fullStr The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
title_full_unstemmed The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
title_short The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer
title_sort role of mitochondrial mirnas in the development of radon-induced lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962319/
https://www.ncbi.nlm.nih.gov/pubmed/35203638
http://dx.doi.org/10.3390/biomedicines10020428
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