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The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression
Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962322/ https://www.ncbi.nlm.nih.gov/pubmed/35203621 http://dx.doi.org/10.3390/biomedicines10020412 |
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author | Cantero-García, Noelia Flores-Burgess, Antonio Ladrón de Guevara-Miranda, David Serrano, Antonia García-Durán, Laura Puigcerver, Araceli Fuxe, Kjell Narváez, José Ángel Santín, Luis Javier Díaz-Cabiale, Zaida Millón, Carmelo |
author_facet | Cantero-García, Noelia Flores-Burgess, Antonio Ladrón de Guevara-Miranda, David Serrano, Antonia García-Durán, Laura Puigcerver, Araceli Fuxe, Kjell Narváez, José Ángel Santín, Luis Javier Díaz-Cabiale, Zaida Millón, Carmelo |
author_sort | Cantero-García, Noelia |
collection | PubMed |
description | Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that could modulate alcohol consumption and depression is necessary. We have analyzed the effect of Galanin (1–15) [GAL(1–15)] on escitalopram (ESC)-mediated effect in alcohol consumption using the alcohol self-administration test, the nuclei involved in the effect, and whether GAL(1–15) + ESC modulated the response in despair or anxiety tests in animals under chronic alcohol intake. GAL(1–15) + ESC combination substantially reduced alcohol intake in the alcohol self-administration test and, moreover, enhanced the reduction of reward capacity of ESC on different reinforcers such as sucrose or saccharine. GAL(1–15) + ESC coadministration significantly decreases the number of C-Fos-IR TH cell bodies in the VTA, and PCA analysis suggests that one functional network, including VTA, RMTg and DR, is involved in these effects. Significantly in rats with chronic alcohol consumption, GAL(1–15) reversed adverse ESC-mediated effects in the depression-related behavioural test and forced swimming test. The results open up the possibility of using GAL(1–15) in combination with the SSRI Escitalopram as a novel strategy in AUD comorbidity with depression. |
format | Online Article Text |
id | pubmed-8962322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89623222022-03-30 The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression Cantero-García, Noelia Flores-Burgess, Antonio Ladrón de Guevara-Miranda, David Serrano, Antonia García-Durán, Laura Puigcerver, Araceli Fuxe, Kjell Narváez, José Ángel Santín, Luis Javier Díaz-Cabiale, Zaida Millón, Carmelo Biomedicines Article Alcohol use disorder (AUD) is highly prevalent, and over 50% of AUD patients also suffer major depressive disorders. Selective 5-HT reuptake inhibitors (SSRIs) can reduce rodent ethanol drinking but exert modest clinical efficacy in alcoholic individuals. Finding new pharmacological strategies that could modulate alcohol consumption and depression is necessary. We have analyzed the effect of Galanin (1–15) [GAL(1–15)] on escitalopram (ESC)-mediated effect in alcohol consumption using the alcohol self-administration test, the nuclei involved in the effect, and whether GAL(1–15) + ESC modulated the response in despair or anxiety tests in animals under chronic alcohol intake. GAL(1–15) + ESC combination substantially reduced alcohol intake in the alcohol self-administration test and, moreover, enhanced the reduction of reward capacity of ESC on different reinforcers such as sucrose or saccharine. GAL(1–15) + ESC coadministration significantly decreases the number of C-Fos-IR TH cell bodies in the VTA, and PCA analysis suggests that one functional network, including VTA, RMTg and DR, is involved in these effects. Significantly in rats with chronic alcohol consumption, GAL(1–15) reversed adverse ESC-mediated effects in the depression-related behavioural test and forced swimming test. The results open up the possibility of using GAL(1–15) in combination with the SSRI Escitalopram as a novel strategy in AUD comorbidity with depression. MDPI 2022-02-09 /pmc/articles/PMC8962322/ /pubmed/35203621 http://dx.doi.org/10.3390/biomedicines10020412 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cantero-García, Noelia Flores-Burgess, Antonio Ladrón de Guevara-Miranda, David Serrano, Antonia García-Durán, Laura Puigcerver, Araceli Fuxe, Kjell Narváez, José Ángel Santín, Luis Javier Díaz-Cabiale, Zaida Millón, Carmelo The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
title | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
title_full | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
title_fullStr | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
title_full_unstemmed | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
title_short | The Combination of Galanin (1–15) and Escitalopram in Rats Suggests a New Strategy for Alcohol Use Disorder Comorbidity with Depression |
title_sort | combination of galanin (1–15) and escitalopram in rats suggests a new strategy for alcohol use disorder comorbidity with depression |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962322/ https://www.ncbi.nlm.nih.gov/pubmed/35203621 http://dx.doi.org/10.3390/biomedicines10020412 |
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