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Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

The mitochondrial pyruvate carrier (MPC) is an inner-mitochondrial membrane protein complex that has emerged as a drug target for treating a variety of human conditions. A heterodimer of two proteins, MPC1 and MPC2, comprises the functional MPC complex in higher organisms; however, the structure of...

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Detalles Bibliográficos
Autores principales:	Hegazy, Lamees, Gill, Lauren E., Pyles, Kelly D., Kaiho, Christopher, Kchouk, Sophia, Finck, Brian N., McCommis, Kyle S., Elgendy, Bahaa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962382/ https://www.ncbi.nlm.nih.gov/pubmed/35203575 http://dx.doi.org/10.3390/biomedicines10020365

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