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One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?

(1) Background: After spending a year wintering in Antarctica, individual expedition members have reported increased or even new allergic reactions to environmental allergens after their return. (2) Methods: Blood samples from five overwintering crews were analyzed using the chip based multiplex ALE...

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Autores principales: Feuerecker, Matthias, Strewe, Claudia, Aumayr, Martina, Heitland, Tim, Limper, Ulrich, Crucian, Brian, Baatout, Sarah, Choukér, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962425/
https://www.ncbi.nlm.nih.gov/pubmed/35203657
http://dx.doi.org/10.3390/biomedicines10020448
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author Feuerecker, Matthias
Strewe, Claudia
Aumayr, Martina
Heitland, Tim
Limper, Ulrich
Crucian, Brian
Baatout, Sarah
Choukér, Alexander
author_facet Feuerecker, Matthias
Strewe, Claudia
Aumayr, Martina
Heitland, Tim
Limper, Ulrich
Crucian, Brian
Baatout, Sarah
Choukér, Alexander
author_sort Feuerecker, Matthias
collection PubMed
description (1) Background: After spending a year wintering in Antarctica, individual expedition members have reported increased or even new allergic reactions to environmental allergens after their return. (2) Methods: Blood samples from five overwintering crews were analyzed using the chip based multiplex ALEX Allergy Explorer (MacroArray Diagnostics GmbH, Austria). (3) Results: About one third of the 39 participants displayed specific IgEs against pollen. In most individuals, kinetics showed a reduction in the specific IgE at the time about nine months after deployment to Antarctica. Five participants had the highest specific IgE levels after returning to the “normal” world. The examination of the specific IgE relative to house dust mites and storage mites showed different kinetics. Six out of 10 had the highest specific IgE concentrations at the inner Antarctic measurement time point. These data corresponded well to the general situation in the stations. At the stations themselves, there were almost no pollen particle load, especially at Concordia. (4) Conclusions: Antarctic long-term confinement can induce an altered immune function, which is in some individuals pronounced after return to the familiar allergen environment. Future prospective studies in larger cohorts are needed to further specify these first results.
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spelling pubmed-89624252022-03-30 One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? Feuerecker, Matthias Strewe, Claudia Aumayr, Martina Heitland, Tim Limper, Ulrich Crucian, Brian Baatout, Sarah Choukér, Alexander Biomedicines Article (1) Background: After spending a year wintering in Antarctica, individual expedition members have reported increased or even new allergic reactions to environmental allergens after their return. (2) Methods: Blood samples from five overwintering crews were analyzed using the chip based multiplex ALEX Allergy Explorer (MacroArray Diagnostics GmbH, Austria). (3) Results: About one third of the 39 participants displayed specific IgEs against pollen. In most individuals, kinetics showed a reduction in the specific IgE at the time about nine months after deployment to Antarctica. Five participants had the highest specific IgE levels after returning to the “normal” world. The examination of the specific IgE relative to house dust mites and storage mites showed different kinetics. Six out of 10 had the highest specific IgE concentrations at the inner Antarctic measurement time point. These data corresponded well to the general situation in the stations. At the stations themselves, there were almost no pollen particle load, especially at Concordia. (4) Conclusions: Antarctic long-term confinement can induce an altered immune function, which is in some individuals pronounced after return to the familiar allergen environment. Future prospective studies in larger cohorts are needed to further specify these first results. MDPI 2022-02-15 /pmc/articles/PMC8962425/ /pubmed/35203657 http://dx.doi.org/10.3390/biomedicines10020448 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feuerecker, Matthias
Strewe, Claudia
Aumayr, Martina
Heitland, Tim
Limper, Ulrich
Crucian, Brian
Baatout, Sarah
Choukér, Alexander
One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?
title One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?
title_full One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?
title_fullStr One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?
title_full_unstemmed One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?
title_short One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?
title_sort one year in the extreme isolation of antarctica—is this enough to modulate an “allergic” sensitization?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962425/
https://www.ncbi.nlm.nih.gov/pubmed/35203657
http://dx.doi.org/10.3390/biomedicines10020448
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