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Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties
Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-indep...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962426/ https://www.ncbi.nlm.nih.gov/pubmed/35203723 http://dx.doi.org/10.3390/biomedicines10020514 |
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author | Carlisi, Daniela Lauricella, Marianna D’Anneo, Antonella De Blasio, Anna Celesia, Adriana Pratelli, Giovanni Notaro, Antonietta Calvaruso, Giuseppe Giuliano, Michela Emanuele, Sonia |
author_facet | Carlisi, Daniela Lauricella, Marianna D’Anneo, Antonella De Blasio, Anna Celesia, Adriana Pratelli, Giovanni Notaro, Antonietta Calvaruso, Giuseppe Giuliano, Michela Emanuele, Sonia |
author_sort | Carlisi, Daniela |
collection | PubMed |
description | Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-independent forms of cell death in many tumor models. The therapeutical potential of PN has been increased by chemical design and synthesis of more soluble analogues including dimethylaminoparthenolide (DMAPT). This review focuses on the molecular mechanisms of both PN and analogues action in tumor models, highlighting their effects on gene expression, signal transduction and execution of different types of cell death. Recent findings indicate that these compounds not only inhibit prosurvival transcriptional factors such as NF-κB and STATs but can also determine the activation of specific death pathways, increasing intracellular reactive oxygen species (ROS) production and modifications of Bcl-2 family members. An intriguing property of these compounds is its specific targeting of cancer stem cells. The unusual actions of PN and its analogues make these agents good candidates for molecular targeted cancer therapy. |
format | Online Article Text |
id | pubmed-8962426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89624262022-03-30 Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties Carlisi, Daniela Lauricella, Marianna D’Anneo, Antonella De Blasio, Anna Celesia, Adriana Pratelli, Giovanni Notaro, Antonietta Calvaruso, Giuseppe Giuliano, Michela Emanuele, Sonia Biomedicines Review Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-independent forms of cell death in many tumor models. The therapeutical potential of PN has been increased by chemical design and synthesis of more soluble analogues including dimethylaminoparthenolide (DMAPT). This review focuses on the molecular mechanisms of both PN and analogues action in tumor models, highlighting their effects on gene expression, signal transduction and execution of different types of cell death. Recent findings indicate that these compounds not only inhibit prosurvival transcriptional factors such as NF-κB and STATs but can also determine the activation of specific death pathways, increasing intracellular reactive oxygen species (ROS) production and modifications of Bcl-2 family members. An intriguing property of these compounds is its specific targeting of cancer stem cells. The unusual actions of PN and its analogues make these agents good candidates for molecular targeted cancer therapy. MDPI 2022-02-21 /pmc/articles/PMC8962426/ /pubmed/35203723 http://dx.doi.org/10.3390/biomedicines10020514 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carlisi, Daniela Lauricella, Marianna D’Anneo, Antonella De Blasio, Anna Celesia, Adriana Pratelli, Giovanni Notaro, Antonietta Calvaruso, Giuseppe Giuliano, Michela Emanuele, Sonia Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties |
title | Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties |
title_full | Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties |
title_fullStr | Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties |
title_full_unstemmed | Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties |
title_short | Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties |
title_sort | parthenolide and its soluble analogues: multitasking compounds with antitumor properties |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962426/ https://www.ncbi.nlm.nih.gov/pubmed/35203723 http://dx.doi.org/10.3390/biomedicines10020514 |
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