Cargando…

Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response

Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. Our aim was to study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gil, Joan, Marques-Pamies, Montserrat, Valassi, Elena, García-Martínez, Araceli, Serra, Guillermo, Hostalot, Cristina, Fajardo-Montañana, Carmen, Carrato, Cristina, Bernabeu, Ignacio, Marazuela, Mónica, Rodríguez-Lloveras, Helena, Cámara, Rosa, Salinas, Isabel, Lamas, Cristina, Biagetti, Betina, Simó-Servat, Andreu, Webb, Susan M., Picó, Antonio, Jordà, Mireia, Puig-Domingo, Manel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962441/ https://www.ncbi.nlm.nih.gov/pubmed/35203668 http://dx.doi.org/10.3390/biomedicines10020460

Ejemplares similares

Data mining analyses for precision medicine in acromegaly: a proof of concept
por: Gil, Joan, et al.
Publicado: (2022)

Pasireotide in the Personalized Treatment of Acromegaly
por: Puig-Domingo, Manel, et al.
Publicado: (2021)

Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
por: Marques-Pamies, Montserrat, et al.
Publicado: (2023)

Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
por: Gil, Joan, et al.
Publicado: (2023)

Preference of acromegaly patients for treatment attributes in Spain
por: Fajardo, Carmen, et al.
Publicado: (2023)

Prolactin and Growth Hormone Signaling and Interlink Focused on the Mammosomatotroph Paradigm: A Comprehensive Review of the Literature
por: Araujo-Castro, Marta, et al.
Publicado: (2023)

Epithelial–Mesenchymal Transition in the Resistance to Somatostatin Receptor Ligands in Acromegaly
por: Gil, Joan, et al.
Publicado: (2021)

Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain
por: Biagetti, Betina, et al.
Publicado: (2022)

Diagnosis, treatment and follow-up of patients with acromegaly in a clinical practice setting in Spain: the ACROPRAXIS program Delphi survey
por: de Pablos-Velasco, Pedro, et al.
Publicado: (2019)

Age-Related Hormones Changes and Its Impact on Health Status and Lifespan
por: Biagetti, Betina, et al.
Publicado: (2023)

Metabolic Fingerprint of Acromegaly and Its Potential Usefulness in Clinical Practice
por: Biagetti, Betina, et al.
Publicado: (2019)

Efficacy and safety of temozolomide in the treatment of aggressive pituitary neuroendocrine tumours in Spain
por: Lamas, Cristina, et al.
Publicado: (2023)

Effectiveness of lanreotide autogel 120 mg at extended dosing intervals for acromegaly
por: Bernabéu, Ignacio, et al.
Publicado: (2020)

Increased E2F1 mRNA and miR-17-5p Expression Is Correlated to Invasiveness and Proliferation of Pituitary Neuroendocrine Tumours
por: García-Martínez, Araceli, et al.
Publicado: (2020)

Prevalence of acromegaly in patients with symptoms of sleep apnea
por: Sesmilo, Gemma, et al.
Publicado: (2017)

GH/IGF-1 Abnormalities and Muscle Impairment: From Basic Research to Clinical Practice
por: Biagetti, Betina, et al.
Publicado: (2021)

Molecular Pathways in Prolactinomas: Translational and Therapeutic Implications
por: Biagetti, Betina, et al.
Publicado: (2021)

Pituitary Apoplexy: Risk Factors and Underlying Molecular Mechanisms
por: Biagetti, Betina, et al.
Publicado: (2022)

Is it time to consider the expression of specific-pituitary hormone genes when typifying pituitary tumours?
por: García-Martínez, Araceli, et al.
Publicado: (2018)

Differential Expression of MicroRNAs in Silent and Functioning Corticotroph Tumors
por: García-Martínez, Araceli, et al.
Publicado: (2020)

How Valuable Is the RT-qPCR of Pituitary-Specific Transcription Factors for Identifying Pituitary Neuroendocrine Tumor Subtypes According to the New WHO 2017 Criteria?
por: Torregrosa-Quesada, María Eugenia, et al.
Publicado: (2019)

Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy
por: Simó-Servat, Olga, et al.
Publicado: (2012)

Genetics in Diabetic Retinopathy: Current Concepts and New Insights
por: Simó-Servat, Olga, et al.
Publicado: (2013)

Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology
por: Simó-Servat, Olga, et al.
Publicado: (2016)

Benign and Malignant Nodular Thyroid Disease in Acromegaly. Is a Routine Thyroid Ultrasound Evaluation Advisable?
por: Reverter, Jordi L., et al.
Publicado: (2014)

SAT-LB078 Acromegaly Disease Activity According to ACRODAT® in Spain: ACROVAL Study
por: Marazuela, Monica, et al.
Publicado: (2019)

Acromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) Database
por: Petrossians, Patrick, et al.
Publicado: (2017)

Acromegaly disease activity according to ACRODAT®, a cross-sectional study in Spain: ACROVAL study
por: Marazuela, Mónica, et al.
Publicado: (2021)

Mechanisms of retinal neuroprotection of calcium dobesilate: therapeutic implications
por: Simó-Servat, Olga, et al.
Publicado: (2017)

Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy
por: Simó, Rafael, et al.
Publicado: (2021)

Advanced Glycations End Products in the Skin as Biomarkers of Cardiovascular Risk in Type 2 Diabetes
por: Planas, Alejandra, et al.
Publicado: (2022)

Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications
por: Ramos, Hugo, et al.
Publicado: (2023)

Bringing Cardiovascular Comorbidities in Acromegaly to an Update. How Should We Diagnose and Manage Them?
por: Ramos-Leví, Ana M., et al.
Publicado: (2019)

Contribution of molecular analysis to the typification of the non-functioning pituitary adenomas
por: Sanchez-Tejada, Laura, et al.
Publicado: (2017)

Acromegaly remission, SIADH and pituitary function recovery after macroadenoma apoplexy
por: Sanz-Sapera, E, et al.
Publicado: (2019)

New Insights into the Mechanisms of Action of Topical Administration of GLP-1 in an Experimental Model of Diabetic Retinopathy
por: Sampedro, Joel, et al.
Publicado: (2019)

Segmental neurofibromatosis type 2: discriminating two hit from four hit in a patient presenting multiple schwannomas confined to one limb
por: Castellanos, Elisabeth, et al.
Publicado: (2015)

Basic mechanisms of SARS-CoV-2 infection. What endocrine systems could be implicated?
por: Soldevila, Berta, et al.
Publicado: (2021)

Vertebral Fractures in Acromegaly: A Systematic Review
por: Sorohan, Madalina Cristina, et al.
Publicado: (2022)

Usefulness of Eye Fixation Assessment for Identifying Type 2 Diabetic Subjects at Risk of Dementia
por: Simó-Servat, Olga, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_71ii37p7s1dbhbr53m0erotmu3