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Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study

BACKGROUND: Pneumonia is a major contributor to hospital admission for patients with chronic obstructive pulmonary disease (COPD). However, evidence for acute effects of ambient air pollution exposure on pneumonia hospital admission among patients with COPD is scarce. We aimed to examine the associa...

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Autores principales: Lu, Wenfeng, Tian, Qi, Xu, Ruijun, Zhong, Chenghui, Qiu, Lan, Zhang, Han, Shi, Chunxiang, Liu, Yuewei, Zhou, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962484/
https://www.ncbi.nlm.nih.gov/pubmed/35346202
http://dx.doi.org/10.1186/s12931-022-01989-9
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author Lu, Wenfeng
Tian, Qi
Xu, Ruijun
Zhong, Chenghui
Qiu, Lan
Zhang, Han
Shi, Chunxiang
Liu, Yuewei
Zhou, Yun
author_facet Lu, Wenfeng
Tian, Qi
Xu, Ruijun
Zhong, Chenghui
Qiu, Lan
Zhang, Han
Shi, Chunxiang
Liu, Yuewei
Zhou, Yun
author_sort Lu, Wenfeng
collection PubMed
description BACKGROUND: Pneumonia is a major contributor to hospital admission for patients with chronic obstructive pulmonary disease (COPD). However, evidence for acute effects of ambient air pollution exposure on pneumonia hospital admission among patients with COPD is scarce. We aimed to examine the association between short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD. METHODS: We enrolled COPD cases aged ≥ 60 years old and further filtered those who were admitted into hospitals from pneumonia during 2016–2019 in Guangdong province, China for main analysis. A time-stratified case-crossover design was applied to investigate the association and conditional logistic regression model was used for data analysis. We performed inverse distance weighting method to estimate daily individual-level exposure on particulate matter with an aerodynamic diameter ≤ 2.5 μm (PM(2.5)), particulate matter with an aerodynamic diameter ≤ 10 μm (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide (NO(2)), carbon monoxide (CO), and ozone (O(3)) based on personal residential addresses. RESULTS: We included 6473 pneumonia hospital admissions during the study period. Each interquartile range (IQR) increase in PM(2.5) (lag 2; IQR, 22.1 μg/m(3)), SO(2) (lag 03; IQR, 4.2 μg/m(3)), NO(2) (lag 03; IQR, 21.4 μg/m(3)), and O(3) (lag 04; IQR, 57.9 μg/m(3)) was associated with an odds ratio in pneumonia hospital admission of 1.043 (95% CI: 1.004–1.083), 1.081 (95% CI: 1.026–1.140), 1.045 (95% CI: 1.005–1.088), and 1.080 (95% CI: 1.018–1.147), respectively. Non-linear trends for PM(2.5), PM(10), and SO(2) were observed in the study. Sex, age at hospital admission, and season at hospital admission did not modify the associations. CONCLUSIONS: We found significantly positive associations of short-term exposure to PM(2.5), SO(2), NO(2), and O(3) with pneumonia hospital admission among COPD patients. It provides new insight for comprehensive pneumonia prevention and treatment among COPD patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12931-022-01989-9.
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spelling pubmed-89624842022-03-30 Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study Lu, Wenfeng Tian, Qi Xu, Ruijun Zhong, Chenghui Qiu, Lan Zhang, Han Shi, Chunxiang Liu, Yuewei Zhou, Yun Respir Res Research BACKGROUND: Pneumonia is a major contributor to hospital admission for patients with chronic obstructive pulmonary disease (COPD). However, evidence for acute effects of ambient air pollution exposure on pneumonia hospital admission among patients with COPD is scarce. We aimed to examine the association between short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD. METHODS: We enrolled COPD cases aged ≥ 60 years old and further filtered those who were admitted into hospitals from pneumonia during 2016–2019 in Guangdong province, China for main analysis. A time-stratified case-crossover design was applied to investigate the association and conditional logistic regression model was used for data analysis. We performed inverse distance weighting method to estimate daily individual-level exposure on particulate matter with an aerodynamic diameter ≤ 2.5 μm (PM(2.5)), particulate matter with an aerodynamic diameter ≤ 10 μm (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide (NO(2)), carbon monoxide (CO), and ozone (O(3)) based on personal residential addresses. RESULTS: We included 6473 pneumonia hospital admissions during the study period. Each interquartile range (IQR) increase in PM(2.5) (lag 2; IQR, 22.1 μg/m(3)), SO(2) (lag 03; IQR, 4.2 μg/m(3)), NO(2) (lag 03; IQR, 21.4 μg/m(3)), and O(3) (lag 04; IQR, 57.9 μg/m(3)) was associated with an odds ratio in pneumonia hospital admission of 1.043 (95% CI: 1.004–1.083), 1.081 (95% CI: 1.026–1.140), 1.045 (95% CI: 1.005–1.088), and 1.080 (95% CI: 1.018–1.147), respectively. Non-linear trends for PM(2.5), PM(10), and SO(2) were observed in the study. Sex, age at hospital admission, and season at hospital admission did not modify the associations. CONCLUSIONS: We found significantly positive associations of short-term exposure to PM(2.5), SO(2), NO(2), and O(3) with pneumonia hospital admission among COPD patients. It provides new insight for comprehensive pneumonia prevention and treatment among COPD patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12931-022-01989-9. BioMed Central 2022-03-26 2022 /pmc/articles/PMC8962484/ /pubmed/35346202 http://dx.doi.org/10.1186/s12931-022-01989-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lu, Wenfeng
Tian, Qi
Xu, Ruijun
Zhong, Chenghui
Qiu, Lan
Zhang, Han
Shi, Chunxiang
Liu, Yuewei
Zhou, Yun
Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study
title Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study
title_full Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study
title_fullStr Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study
title_full_unstemmed Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study
title_short Short-term exposure to ambient air pollution and pneumonia hospital admission among patients with COPD: a time-stratified case-crossover study
title_sort short-term exposure to ambient air pollution and pneumonia hospital admission among patients with copd: a time-stratified case-crossover study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962484/
https://www.ncbi.nlm.nih.gov/pubmed/35346202
http://dx.doi.org/10.1186/s12931-022-01989-9
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