HBx inhibits DNA sensing signaling pathway via ubiquitination and autophagy of cGAS

BACKGROUND: Cyclic GMP-AMP synthase (cGAS) is a crucial DNA sensor and plays an important role in host antiviral innate immune responses. During hepatitis B virus (HBV) infection, the cGAS signaling pathway can suppress HBV replication. As an important regulatory protein of HBV, hepatitis B virus X...

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Detalles Bibliográficos
Autores principales: Chen, Hong, Jiang, Linshan, Chen, Shu, Hu, Qin, Huang, Ying, Wu, Ying, Chen, Weixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962493/
https://www.ncbi.nlm.nih.gov/pubmed/35346247
http://dx.doi.org/10.1186/s12985-022-01785-3

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