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Clinical significance of FBXW7 loss of function in human cancers

FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in phosphorylation-dependent ubiquitination and proteasome degradation of onc...

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Detalles Bibliográficos
Autores principales:	Fan, Jingyi, Bellon, Marcia, Ju, Mingyi, Zhao, Lin, Wei, Minjie, Fu, Liwu, Nicot, Christophe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962602/ https://www.ncbi.nlm.nih.gov/pubmed/35346215 http://dx.doi.org/10.1186/s12943-022-01548-2

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