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Maternal tobacco smoke exposure is associated with increased DNA methylation at human metastable epialleles in infant cord blood

Metastable epialleles (MEs) are genomic regions that are stochastically methylated prior to germ layer specification and exhibit high interindividual but low intra-individual variability across tissues. ME methylation is vulnerable to environmental stressors, including diet. Tobacco smoke (TS) expos...

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Detalles Bibliográficos
Autores principales: Joglekar, Rashmi, Grenier, Carole, Hoyo, Cathrine, Hoffman, Kate, Murphy, Susan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962709/
https://www.ncbi.nlm.nih.gov/pubmed/35355955
http://dx.doi.org/10.1093/eep/dvac005