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Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease

BACKGROUND: To explore the long-term efficacy and safety of resection of the lateral wall of the endolymphatic sac for the treatment of intractable Meniere's disease (MD) as an alternative surgical procedure for treating this disorder. METHODS: Data from 73 patients who were referred to our hos...

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Autores principales: Zhang, Daogong, Lv, Yafeng, Li, Xiaofei, Song, Yongdong, Kong, Ligang, Fan, Zhaomin, Wang, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962735/
https://www.ncbi.nlm.nih.gov/pubmed/35359640
http://dx.doi.org/10.3389/fneur.2022.827462
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author Zhang, Daogong
Lv, Yafeng
Li, Xiaofei
Song, Yongdong
Kong, Ligang
Fan, Zhaomin
Wang, Haibo
author_facet Zhang, Daogong
Lv, Yafeng
Li, Xiaofei
Song, Yongdong
Kong, Ligang
Fan, Zhaomin
Wang, Haibo
author_sort Zhang, Daogong
collection PubMed
description BACKGROUND: To explore the long-term efficacy and safety of resection of the lateral wall of the endolymphatic sac for the treatment of intractable Meniere's disease (MD) as an alternative surgical procedure for treating this disorder. METHODS: Data from 73 patients who were referred to our hospital and diagnosed with unilateral MD between January 2015 and June 2019 were retrospectively analyzed in this study. Seventy-three patients who had frequent vertigo even after receiving standardized conservative treatment for at least half a year underwent resection of the lateral wall of the endolymphatic sac. Vertigo control and auditory function were assessed. Pure tone audiometry, caloric test, and vestibular evoked myogenic potential were performed to evaluate audiological and vestibular functions. The post-operative follow-up duration was more than 2 years. RESULTS: Among the 73 patients (male 34 cases, female 39 cases; age 20–69 years, average 51.4), vertigo was controlled effectively for 66 cases (90.4%) after 2 years of follow-up; 45 cases (61.6%) were completely controlled, and 21 cases (28.8%) were substantially controlled in this study. The patients of 16.4% had hearing loss with more than 10 dB change based on the four-tone average (0.5, 1, 2 and 3 kHz). No patient had a facial nerve weakness, cerebrospinal fluid leakage, or other complications. CONCLUSION: Resection of the lateral wall of the endolymphatic sac, which can effectively control vertiginous symptoms in intractable MD patients, represents an effective and safe therapy for this disease. Resection of the lateral wall of the endolymphatic sac is expected to be used as an alternative treatment for MD.
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spelling pubmed-89627352022-03-30 Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease Zhang, Daogong Lv, Yafeng Li, Xiaofei Song, Yongdong Kong, Ligang Fan, Zhaomin Wang, Haibo Front Neurol Neurology BACKGROUND: To explore the long-term efficacy and safety of resection of the lateral wall of the endolymphatic sac for the treatment of intractable Meniere's disease (MD) as an alternative surgical procedure for treating this disorder. METHODS: Data from 73 patients who were referred to our hospital and diagnosed with unilateral MD between January 2015 and June 2019 were retrospectively analyzed in this study. Seventy-three patients who had frequent vertigo even after receiving standardized conservative treatment for at least half a year underwent resection of the lateral wall of the endolymphatic sac. Vertigo control and auditory function were assessed. Pure tone audiometry, caloric test, and vestibular evoked myogenic potential were performed to evaluate audiological and vestibular functions. The post-operative follow-up duration was more than 2 years. RESULTS: Among the 73 patients (male 34 cases, female 39 cases; age 20–69 years, average 51.4), vertigo was controlled effectively for 66 cases (90.4%) after 2 years of follow-up; 45 cases (61.6%) were completely controlled, and 21 cases (28.8%) were substantially controlled in this study. The patients of 16.4% had hearing loss with more than 10 dB change based on the four-tone average (0.5, 1, 2 and 3 kHz). No patient had a facial nerve weakness, cerebrospinal fluid leakage, or other complications. CONCLUSION: Resection of the lateral wall of the endolymphatic sac, which can effectively control vertiginous symptoms in intractable MD patients, represents an effective and safe therapy for this disease. Resection of the lateral wall of the endolymphatic sac is expected to be used as an alternative treatment for MD. Frontiers Media S.A. 2022-03-11 /pmc/articles/PMC8962735/ /pubmed/35359640 http://dx.doi.org/10.3389/fneur.2022.827462 Text en Copyright © 2022 Zhang, Lv, Li, Song, Kong, Fan and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Zhang, Daogong
Lv, Yafeng
Li, Xiaofei
Song, Yongdong
Kong, Ligang
Fan, Zhaomin
Wang, Haibo
Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease
title Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease
title_full Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease
title_fullStr Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease
title_full_unstemmed Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease
title_short Efficacy of Resection of Lateral Wall of Endolymphatic Sac for Treatment of Meniere's Disease
title_sort efficacy of resection of lateral wall of endolymphatic sac for treatment of meniere's disease
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962735/
https://www.ncbi.nlm.nih.gov/pubmed/35359640
http://dx.doi.org/10.3389/fneur.2022.827462
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