Cannabidiol inhibits RAD51 and sensitizes glioblastoma to temozolomide in multiple orthotopic tumor models

BACKGROUND: Cannabidiol (CBD), a nonpsychoactive cannabinoid with a low toxicity profile, has been shown to produce antitumor activity across cancers in part through selective production of reactive oxygen species (ROS) in tumor cells. The alkylating agent, temozolomide (TMZ), is standard of care fo...

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Detalles Bibliográficos
Autores principales: Soroceanu, Liliana, Singer, Eric, Dighe, Pratiksha, Sidorov, Max, Limbad, Chandani, Rodriquez-Brotons, Aida, Rix, Peter, Woo, Rinette W L, Dickinson, Lawrence, Desprez, Pierre-Yves, McAllister, Sean D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962752/
https://www.ncbi.nlm.nih.gov/pubmed/35356807
http://dx.doi.org/10.1093/noajnl/vdac019

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