Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infe...

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Detalles Bibliográficos
Autores principales: Laing, Eric D., Weiss, Carol D., Samuels, Emily C., Coggins, Si’Ana A., Wang, Wei, Wang, Richard, Vassell, Russell, Sterling, Spencer L., Tso, Marana S., Conner, Tonia, Goguet, Emilie, Moser, Matthew, Jackson-Thompson, Belinda M., Illinik, Luca, Davies, Julian, Ortega, Orlando, Parmelee, Edward, Hollis-Perry, Monique, Maiolatesi, Santina E., Wang, Gregory, Ramsey, Kathleen F., Reyes, Anatalio E., Alcorta, Yolanda, Wong, Mimi A., Lindrose, Alyssa R., Duplessis, Christopher A., Tribble, David R., Malloy, Allison M.W., Burgess, Timothy H., Pollett, Simon D., Olsen, Cara H., Broder, Christopher C., Mitre, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962883/
https://www.ncbi.nlm.nih.gov/pubmed/35203111
http://dx.doi.org/10.3201/eid2804.212037
Descripción
Sumario:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.

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