A Novel Modulator of the Renin–Angiotensin System, Benzoylaconitine, Attenuates Hypertension by Targeting ACE/ACE2 in Enhancing Vasodilation and Alleviating Vascular Inflammation

The monoester alkaloids in Aconitum carmichaelii, including benzoylaconitine (BAC), benzoylmesaconine, and benzoylhypaconitine, were found to have anti-hypertensive effects in spontaneously hypertension rats (SHRs), of which BAC is the strongest. However, its antihypertensive target and underlying m...

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Detalles Bibliográficos
Autores principales: Zhang, Qi-Qiang, Chen, Feng-Hua, Wang, Fei, Di, Xue-Mei, Li, Wei, Zhang, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963105/
https://www.ncbi.nlm.nih.gov/pubmed/35359841
http://dx.doi.org/10.3389/fphar.2022.841435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963105/
https://www.ncbi.nlm.nih.gov/pubmed/35359841
http://dx.doi.org/10.3389/fphar.2022.841435

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