Cargando…

A Novel Modulator of the Renin–Angiotensin System, Benzoylaconitine, Attenuates Hypertension by Targeting ACE/ACE2 in Enhancing Vasodilation and Alleviating Vascular Inflammation

The monoester alkaloids in Aconitum carmichaelii, including benzoylaconitine (BAC), benzoylmesaconine, and benzoylhypaconitine, were found to have anti-hypertensive effects in spontaneously hypertension rats (SHRs), of which BAC is the strongest. However, its antihypertensive target and underlying m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Qi-Qiang, Chen, Feng-Hua, Wang, Fei, Di, Xue-Mei, Li, Wei, Zhang, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963105/ https://www.ncbi.nlm.nih.gov/pubmed/35359841 http://dx.doi.org/10.3389/fphar.2022.841435

Ejemplares similares

Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats
por: Gonzalez, Alexis A., et al.
Publicado: (2019)

Three key proteases – angiotensin-I-converting enzyme (ACE), ACE2 and renin – within and beyond the renin-angiotensin system
por: Guang, Cuie, et al.
Publicado: (2012)

ACE2, a new regulator of the renin–angiotensin system
por: Burrell, Louise M., et al.
Publicado: (2004)

Benzoylaconitine Alleviates Progression of Psoriasis via Suppressing STAT3 Phosphorylation in Keratinocytes
por: Li, Yuanbo, et al.
Publicado: (2023)

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
por: Jiang, Xiao, et al.
Publicado: (2020)

Relationship Between ACE2 and Other Components of the Renin-Angiotensin System
por: Cohen, Jordana B., et al.
Publicado: (2020)

ACE2 – From the renin–angiotensin system to gut microbiota and malnutrition
por: Perlot, Thomas, et al.
Publicado: (2013)

Devil and angel in the renin–angiotensin system: ACE–angiotensin II–AT(1) receptor axis vs. ACE2–angiotensin-(1–7)–Mas receptor axis
por: Iwai, Masaru, et al.
Publicado: (2009)

The Yin and Yang of ACE/ACE2 Pathways: The Rationale for the Use of Renin-Angiotensin System Inhibitors in COVID-19 Patients
por: Zamai, Loris
Publicado: (2020)

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2
por: Clayton, Daniel, et al.
Publicado: (2015)

Physical Activity and Inhibition of ACE Additively Modulate ACE/ACE-2 Balance in Heart Failure in Mice
por: Tyrankiewicz, Urszula, et al.
Publicado: (2021)

Downregulation of ACE2 induces overstimulation of the renin–angiotensin system in COVID-19: should we block the renin–angiotensin system?
por: Silhol, François, et al.
Publicado: (2020)

Biological sex differences in renin angiotensin system enzymes ACE and ACE2 regulate normal tissue response to radiation injury
por: Sharma, Guru Prasad, et al.
Publicado: (2023)

Increased plasma renin by vasodilators promotes the progression of abdominal aortic aneurysm
por: Liu, Yu, et al.
Publicado: (2023)

ACE2, the Counter-Regulatory Renin–Angiotensin System Axis and COVID-19 Severity
por: Triposkiadis, Filippos, et al.
Publicado: (2021)

The Changes of Serum-ACE, Plasma Renin Activity and Aldosterone in the Diabetics with Hypertension
por: Oh, Jung Kyun, et al.
Publicado: (1986)

Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease
por: Tikellis, Chris, et al.
Publicado: (2012)

New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) I: Endogenous Angiotensin Converting Enzyme (ACE) Inhibition
por: Fagyas, Miklós, et al.
Publicado: (2014)

Angiotensin(1-7) and ACE2, “The Hot Spots” of Renin-Angiotensin System, Detected in the Human Aqueous Humor
por: Holappa, Mervi, et al.
Publicado: (2015)

Recombinant human ACE2: acing out angiotensin II in ARDS therapy
por: Zhang, Haibo, et al.
Publicado: (2017)

Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies
por: Abubakar, Murtala Bello, et al.
Publicado: (2021)

ACE2 and Angiotensin-(1-7) in Hypertensive Renal Disease
por: Moon, Ju-Young
Publicado: (2011)

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling
por: Clarke, Nicola E., et al.
Publicado: (2012)

The Renin-Angiotensin system and SARS-CoV-2 infection: A role for the ACE2 receptor?
por: Sever, Peter, et al.
Publicado: (2020)

Implications of testicular ACE2 and the renin–angiotensin system for SARS-CoV-2 on testis function
por: Edenfield, R. Clayton, et al.
Publicado: (2021)

New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) II: Albumin Suppresses Angiotensin Converting Enzyme (ACE) Activity in Human
por: Fagyas, Miklós, et al.
Publicado: (2014)

Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?—Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice—
por: Takeshita, Hikari, et al.
Publicado: (2023)

Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase
por: Yan, Xiao, et al.
Publicado: (2020)

Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System
por: Yang, Mengying, et al.
Publicado: (2020)

The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19
por: Ekholm, M., et al.
Publicado: (2021)

The Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling
por: Pacurari, Maricica, et al.
Publicado: (2014)

The effect of renin–angiotensin–aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19
por: Kim, Gha-hyun J., et al.
Publicado: (2021)

Angiotensin-Converting Enzyme (ACE) level, but not ACE gene polymorphism, is associated with prognosis of COVID-19 infection: Implications for diabetes and hypertension
por: Elbasan, Onur, et al.
Publicado: (2023)

Recombinant Expression and Characterization of Human and Murine ACE2: Species-Specific Activation of the Alternative Renin-Angiotensin-System
por: Poglitsch, Marko, et al.
Publicado: (2012)

Role of Renin–Angiotensin-converting Enzyme Level and ACE Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease
por: Tekatas, Demet D, et al.
Publicado: (2016)

Role of the Backbenchers of the Renin-Angiotensin System ACE2 and AT2 Receptors in COVID-19: Lessons From SARS
por: Gumashta, Jyotsna, et al.
Publicado: (2020)

Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7
por: Silva, Gabriela M., et al.
Publicado: (2020)

Interactions between ibuprofen, ACE2, renin‐angiotensin system, and spike protein in the lung. Implications for COVID‐19
por: Valenzuela, Rita, et al.
Publicado: (2021)

Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts
por: Marfella, Raffaele, et al.
Publicado: (2022)

Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2)
por: Zemlin, Annalise E, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d5uo7vutqaav01bdqspg1f301c