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Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis
The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as being associated with acute Sars-Cov-2 infection and post-COVID-19 syndrome. The exact mechanisms and histopathological correlations underlying thyroid involvement remained unresolved, but current insights...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963172/ https://www.ncbi.nlm.nih.gov/pubmed/35166214 http://dx.doi.org/10.1530/ETJ-22-0005 |
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author | Jakovac, Hrvoje Ferenčić, Antun Stemberger, Christophe Mohar Vitezić, Bojana Cuculić, Dražen |
author_facet | Jakovac, Hrvoje Ferenčić, Antun Stemberger, Christophe Mohar Vitezić, Bojana Cuculić, Dražen |
author_sort | Jakovac, Hrvoje |
collection | PubMed |
description | The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as being associated with acute Sars-Cov-2 infection and post-COVID-19 syndrome. The exact mechanisms and histopathological correlations underlying thyroid involvement remained unresolved, but current insights suggest either direct viral damage, systemic inflammatory reaction, or an autoimmune response as possible noxious effectors. Here we present findings of immunohistochemical/immunofluorescence detection of Sars-Cov-2 viral proteins (spike/S and nucleocapside proteins) in relation to histoarchitectonic changes of autoptic thyroid tissue obtained from patient who deceased from COVID-19. |
format | Online Article Text |
id | pubmed-8963172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-89631722022-03-30 Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis Jakovac, Hrvoje Ferenčić, Antun Stemberger, Christophe Mohar Vitezić, Bojana Cuculić, Dražen Eur Thyroid J Case Report The clinical and laboratory findings of subacute thyroiditis have been repeatedly reported as being associated with acute Sars-Cov-2 infection and post-COVID-19 syndrome. The exact mechanisms and histopathological correlations underlying thyroid involvement remained unresolved, but current insights suggest either direct viral damage, systemic inflammatory reaction, or an autoimmune response as possible noxious effectors. Here we present findings of immunohistochemical/immunofluorescence detection of Sars-Cov-2 viral proteins (spike/S and nucleocapside proteins) in relation to histoarchitectonic changes of autoptic thyroid tissue obtained from patient who deceased from COVID-19. Bioscientifica Ltd 2022-02-15 /pmc/articles/PMC8963172/ /pubmed/35166214 http://dx.doi.org/10.1530/ETJ-22-0005 Text en © The authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Case Report Jakovac, Hrvoje Ferenčić, Antun Stemberger, Christophe Mohar Vitezić, Bojana Cuculić, Dražen Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis |
title | Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis |
title_full | Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis |
title_fullStr | Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis |
title_full_unstemmed | Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis |
title_short | Detection of Sars-Cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis |
title_sort | detection of sars-cov-2 antigens in thyroid gland showing histopathological features of subacute thyroiditis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963172/ https://www.ncbi.nlm.nih.gov/pubmed/35166214 http://dx.doi.org/10.1530/ETJ-22-0005 |
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