Cargando…

The difference of the inflammatory milieu in MIS-C and severe COVID-19

BACKGROUND: Coronavirus disease 19 (COVID-19) may have a severe course in children. Multisystem inflammatory syndrome in children (MIS-C) is the post-COVID complication characterized by an exaggerated inflammation, observed in children. However, data on the underlying pathophysiology are sparse. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Gurlevik, Sibel Lacinel, Ozsurekci, Yasemin, Sağ, Erdal, Derin Oygar, P., Kesici, Selman, Akca, Ümmüşen Kaya, Cuceoglu, Muserref Kasap, Basaran, Ozge, Göncü, Sultan, Karakaya, Jale, Cengiz, Ali Bülent, Özen, Seza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963396/
https://www.ncbi.nlm.nih.gov/pubmed/35352005
http://dx.doi.org/10.1038/s41390-022-02029-4
_version_ 1784677981201891328
author Gurlevik, Sibel Lacinel
Ozsurekci, Yasemin
Sağ, Erdal
Derin Oygar, P.
Kesici, Selman
Akca, Ümmüşen Kaya
Cuceoglu, Muserref Kasap
Basaran, Ozge
Göncü, Sultan
Karakaya, Jale
Cengiz, Ali Bülent
Özen, Seza
author_facet Gurlevik, Sibel Lacinel
Ozsurekci, Yasemin
Sağ, Erdal
Derin Oygar, P.
Kesici, Selman
Akca, Ümmüşen Kaya
Cuceoglu, Muserref Kasap
Basaran, Ozge
Göncü, Sultan
Karakaya, Jale
Cengiz, Ali Bülent
Özen, Seza
author_sort Gurlevik, Sibel Lacinel
collection PubMed
description BACKGROUND: Coronavirus disease 19 (COVID-19) may have a severe course in children. Multisystem inflammatory syndrome in children (MIS-C) is the post-COVID complication characterized by an exaggerated inflammation, observed in children. However, data on the underlying pathophysiology are sparse. We therefore aimed to assess the cytokine and chemokine profiles of children with MIS-C and compare these to life-threatening severe SARS-CoV-2 and healthy controls (HCs) to shed light on disease pathophysiology. METHODS: Samples of 31 children with MIS-C, 10 with severe/critical COVID-19 and 11 HCs were included. Cytokine and chemokine profiles were studied and compared in between groups. RESULTS: Most cytokines and chemokines related to IL-1 family and IFN-γ pathway (including IL-18 and MIG/CXCL9) and IL-17A were significantly higher in the MIS-C group when compared to the severe/critical COVID-19 group and HCs. IP-10/CXCL10 and IL-10 were higher in both MIS-C patients and severe/critical COVID-19 compared to HCs. CONCLUSION: Our results suggest that IL-1 and IFN-γ pathways play an important role in the pathophysiology of MIS-C. IMPACT: This study defines a pattern of distinctive immune responses in children with MIS-C and in patients with severe/critical COVID-19. As the COVID-19 pandemic continues, biomarkers to identify MIS-C risk are needed to guide our management that study results may shed light on it.
format Online
Article
Text
id pubmed-8963396
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group US
record_format MEDLINE/PubMed
spelling pubmed-89633962022-03-30 The difference of the inflammatory milieu in MIS-C and severe COVID-19 Gurlevik, Sibel Lacinel Ozsurekci, Yasemin Sağ, Erdal Derin Oygar, P. Kesici, Selman Akca, Ümmüşen Kaya Cuceoglu, Muserref Kasap Basaran, Ozge Göncü, Sultan Karakaya, Jale Cengiz, Ali Bülent Özen, Seza Pediatr Res Population Study Article BACKGROUND: Coronavirus disease 19 (COVID-19) may have a severe course in children. Multisystem inflammatory syndrome in children (MIS-C) is the post-COVID complication characterized by an exaggerated inflammation, observed in children. However, data on the underlying pathophysiology are sparse. We therefore aimed to assess the cytokine and chemokine profiles of children with MIS-C and compare these to life-threatening severe SARS-CoV-2 and healthy controls (HCs) to shed light on disease pathophysiology. METHODS: Samples of 31 children with MIS-C, 10 with severe/critical COVID-19 and 11 HCs were included. Cytokine and chemokine profiles were studied and compared in between groups. RESULTS: Most cytokines and chemokines related to IL-1 family and IFN-γ pathway (including IL-18 and MIG/CXCL9) and IL-17A were significantly higher in the MIS-C group when compared to the severe/critical COVID-19 group and HCs. IP-10/CXCL10 and IL-10 were higher in both MIS-C patients and severe/critical COVID-19 compared to HCs. CONCLUSION: Our results suggest that IL-1 and IFN-γ pathways play an important role in the pathophysiology of MIS-C. IMPACT: This study defines a pattern of distinctive immune responses in children with MIS-C and in patients with severe/critical COVID-19. As the COVID-19 pandemic continues, biomarkers to identify MIS-C risk are needed to guide our management that study results may shed light on it. Nature Publishing Group US 2022-03-29 2022 /pmc/articles/PMC8963396/ /pubmed/35352005 http://dx.doi.org/10.1038/s41390-022-02029-4 Text en © The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Population Study Article
Gurlevik, Sibel Lacinel
Ozsurekci, Yasemin
Sağ, Erdal
Derin Oygar, P.
Kesici, Selman
Akca, Ümmüşen Kaya
Cuceoglu, Muserref Kasap
Basaran, Ozge
Göncü, Sultan
Karakaya, Jale
Cengiz, Ali Bülent
Özen, Seza
The difference of the inflammatory milieu in MIS-C and severe COVID-19
title The difference of the inflammatory milieu in MIS-C and severe COVID-19
title_full The difference of the inflammatory milieu in MIS-C and severe COVID-19
title_fullStr The difference of the inflammatory milieu in MIS-C and severe COVID-19
title_full_unstemmed The difference of the inflammatory milieu in MIS-C and severe COVID-19
title_short The difference of the inflammatory milieu in MIS-C and severe COVID-19
title_sort difference of the inflammatory milieu in mis-c and severe covid-19
topic Population Study Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963396/
https://www.ncbi.nlm.nih.gov/pubmed/35352005
http://dx.doi.org/10.1038/s41390-022-02029-4
work_keys_str_mv AT gurleviksibellacinel thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT ozsurekciyasemin thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT sagerdal thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT derinoygarp thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT kesiciselman thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT akcaummusenkaya thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT cuceoglumuserrefkasap thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT basaranozge thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT goncusultan thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT karakayajale thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT cengizalibulent thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT ozenseza thedifferenceoftheinflammatorymilieuinmiscandseverecovid19
AT gurleviksibellacinel differenceoftheinflammatorymilieuinmiscandseverecovid19
AT ozsurekciyasemin differenceoftheinflammatorymilieuinmiscandseverecovid19
AT sagerdal differenceoftheinflammatorymilieuinmiscandseverecovid19
AT derinoygarp differenceoftheinflammatorymilieuinmiscandseverecovid19
AT kesiciselman differenceoftheinflammatorymilieuinmiscandseverecovid19
AT akcaummusenkaya differenceoftheinflammatorymilieuinmiscandseverecovid19
AT cuceoglumuserrefkasap differenceoftheinflammatorymilieuinmiscandseverecovid19
AT basaranozge differenceoftheinflammatorymilieuinmiscandseverecovid19
AT goncusultan differenceoftheinflammatorymilieuinmiscandseverecovid19
AT karakayajale differenceoftheinflammatorymilieuinmiscandseverecovid19
AT cengizalibulent differenceoftheinflammatorymilieuinmiscandseverecovid19
AT ozenseza differenceoftheinflammatorymilieuinmiscandseverecovid19