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The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization

Behçet’s disease (BD) is a systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, cutaneous inflammation, and uveitis. In addition, other potentially life-threatening lesions may occur in the intestinal tract, blood vessels, and central nervous system. This heterogenei...

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Autores principales: Hirahara, Lisa, Takase-Minegishi, Kaoru, Kirino, Yohei, Iizuka-Iribe, Yuki, Soejima, Yutaro, Yoshimi, Ryusuke, Nakajima, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963421/
https://www.ncbi.nlm.nih.gov/pubmed/35359926
http://dx.doi.org/10.3389/fimmu.2022.852297
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author Hirahara, Lisa
Takase-Minegishi, Kaoru
Kirino, Yohei
Iizuka-Iribe, Yuki
Soejima, Yutaro
Yoshimi, Ryusuke
Nakajima, Hideaki
author_facet Hirahara, Lisa
Takase-Minegishi, Kaoru
Kirino, Yohei
Iizuka-Iribe, Yuki
Soejima, Yutaro
Yoshimi, Ryusuke
Nakajima, Hideaki
author_sort Hirahara, Lisa
collection PubMed
description Behçet’s disease (BD) is a systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, cutaneous inflammation, and uveitis. In addition, other potentially life-threatening lesions may occur in the intestinal tract, blood vessels, and central nervous system. This heterogeneity of the BD phenotype hampers development of a targeted treatment strategy. The pathogenesis of BD is not fully elucidated, but it is likely that genetically susceptible people develop BD in response to environmental factors, such as microbiome factors. Genetic analyses have identified various BD susceptibility loci that function in HLA-antigen presentation pathways, Th1 and Th17 cells, and autoinflammation related to monocytes/macrophages, or that increase levels of pro-inflammatory cytokines, reduce levels of anti-inflammatory cytokines, or act in dysfunctional mucous barriers. Our functional analyses have revealed that impairment of M2 monocyte/macrophage-mediated anti-inflammatory function through IL-10 is crucial to BD pathogenesis. We, therefore, propose that BD is an M1-dominant disease. In this review, we describe the roles of monocytes and macrophages in BD and consider the potential of these cells as therapeutic targets.
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spelling pubmed-89634212022-03-30 The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization Hirahara, Lisa Takase-Minegishi, Kaoru Kirino, Yohei Iizuka-Iribe, Yuki Soejima, Yutaro Yoshimi, Ryusuke Nakajima, Hideaki Front Immunol Immunology Behçet’s disease (BD) is a systemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, cutaneous inflammation, and uveitis. In addition, other potentially life-threatening lesions may occur in the intestinal tract, blood vessels, and central nervous system. This heterogeneity of the BD phenotype hampers development of a targeted treatment strategy. The pathogenesis of BD is not fully elucidated, but it is likely that genetically susceptible people develop BD in response to environmental factors, such as microbiome factors. Genetic analyses have identified various BD susceptibility loci that function in HLA-antigen presentation pathways, Th1 and Th17 cells, and autoinflammation related to monocytes/macrophages, or that increase levels of pro-inflammatory cytokines, reduce levels of anti-inflammatory cytokines, or act in dysfunctional mucous barriers. Our functional analyses have revealed that impairment of M2 monocyte/macrophage-mediated anti-inflammatory function through IL-10 is crucial to BD pathogenesis. We, therefore, propose that BD is an M1-dominant disease. In this review, we describe the roles of monocytes and macrophages in BD and consider the potential of these cells as therapeutic targets. Frontiers Media S.A. 2022-03-11 /pmc/articles/PMC8963421/ /pubmed/35359926 http://dx.doi.org/10.3389/fimmu.2022.852297 Text en Copyright © 2022 Hirahara, Takase-Minegishi, Kirino, Iizuka-Iribe, Soejima, Yoshimi and Nakajima https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Hirahara, Lisa
Takase-Minegishi, Kaoru
Kirino, Yohei
Iizuka-Iribe, Yuki
Soejima, Yutaro
Yoshimi, Ryusuke
Nakajima, Hideaki
The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization
title The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization
title_full The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization
title_fullStr The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization
title_full_unstemmed The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization
title_short The Roles of Monocytes and Macrophages in Behçet’s Disease With Focus on M1 and M2 Polarization
title_sort roles of monocytes and macrophages in behçet’s disease with focus on m1 and m2 polarization
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963421/
https://www.ncbi.nlm.nih.gov/pubmed/35359926
http://dx.doi.org/10.3389/fimmu.2022.852297
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