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WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey

WU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens. So far, it has not been proven whether WUPyV is a real causative agent for respiratory diseases. In this study, we described two patients with fatal infection who had WUPyV detect...

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Autores principales: Zhao, Hongwei, Xu, Wenmiao, Wang, Lijuan, Zhu, Yun, Wang, Xiaohui, Liu, Yingchao, Ai, Junhong, Feng, Qianyu, Deng, Li, Sun, Yun, Li, Changchong, Jin, Rong, Shang, Yunxiao, Gao, Hengmiao, Qian, Suyun, Xu, Lili, Xie, Zhengde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963484/
https://www.ncbi.nlm.nih.gov/pubmed/35360221
http://dx.doi.org/10.3389/fcimb.2021.835946
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author Zhao, Hongwei
Xu, Wenmiao
Wang, Lijuan
Zhu, Yun
Wang, Xiaohui
Liu, Yingchao
Ai, Junhong
Feng, Qianyu
Deng, Li
Sun, Yun
Li, Changchong
Jin, Rong
Shang, Yunxiao
Gao, Hengmiao
Qian, Suyun
Xu, Lili
Xie, Zhengde
author_facet Zhao, Hongwei
Xu, Wenmiao
Wang, Lijuan
Zhu, Yun
Wang, Xiaohui
Liu, Yingchao
Ai, Junhong
Feng, Qianyu
Deng, Li
Sun, Yun
Li, Changchong
Jin, Rong
Shang, Yunxiao
Gao, Hengmiao
Qian, Suyun
Xu, Lili
Xie, Zhengde
author_sort Zhao, Hongwei
collection PubMed
description WU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens. So far, it has not been proven whether WUPyV is a real causative agent for respiratory diseases. In this study, we described two patients with fatal infection who had WUPyV detected in their nasopharyngeal swabs. Furthermore, we conducted a multicentre study in six hospitals from different districts of China. WUPyV was detected by real-time polymerase chain reaction assays, and the clinical and molecular epidemiological characteristics of WUPyV strains among hospitalized children with acute lower respiratory tract infections all around China from 2017 to 2019 were analysed. Two complete WUPyV genome sequences were assembled from fatal patients’ airway specimens. Phylogenetic tree analysis revealed that they were most closely related to strains derived from Fujian and Chongqing, China, in 2008 and 2013, respectively. In 2017–2019, a total of 1,812 samples from children with acute lower respiratory tract infections were detected for WUPyV, of which 11 (0.6%) were positive. Children aged ≤5 were more susceptible to WUPyV infection. A total of 81.8% of WUPyV-positive patients were coinfected with other viruses, of which rhinovirus enjoyed the highest frequency. The main clinical symptoms of infected patients include fever, coughing and sputum expectoration. Most patients were diagnosed with pneumonia, followed by bronchial surgery. Three patients manifested severe infection, and all patients improved and were discharged. Our results show that WUPyV persistently circulates in China. Further investigations on the clinical role and pathogenicity of WUPyV are necessary.
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spelling pubmed-89634842022-03-30 WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey Zhao, Hongwei Xu, Wenmiao Wang, Lijuan Zhu, Yun Wang, Xiaohui Liu, Yingchao Ai, Junhong Feng, Qianyu Deng, Li Sun, Yun Li, Changchong Jin, Rong Shang, Yunxiao Gao, Hengmiao Qian, Suyun Xu, Lili Xie, Zhengde Front Cell Infect Microbiol Cellular and Infection Microbiology WU polyomavirus (WUPyV) is a novel member of the family Polyomaviridae recently detected in respiratory tract specimens. So far, it has not been proven whether WUPyV is a real causative agent for respiratory diseases. In this study, we described two patients with fatal infection who had WUPyV detected in their nasopharyngeal swabs. Furthermore, we conducted a multicentre study in six hospitals from different districts of China. WUPyV was detected by real-time polymerase chain reaction assays, and the clinical and molecular epidemiological characteristics of WUPyV strains among hospitalized children with acute lower respiratory tract infections all around China from 2017 to 2019 were analysed. Two complete WUPyV genome sequences were assembled from fatal patients’ airway specimens. Phylogenetic tree analysis revealed that they were most closely related to strains derived from Fujian and Chongqing, China, in 2008 and 2013, respectively. In 2017–2019, a total of 1,812 samples from children with acute lower respiratory tract infections were detected for WUPyV, of which 11 (0.6%) were positive. Children aged ≤5 were more susceptible to WUPyV infection. A total of 81.8% of WUPyV-positive patients were coinfected with other viruses, of which rhinovirus enjoyed the highest frequency. The main clinical symptoms of infected patients include fever, coughing and sputum expectoration. Most patients were diagnosed with pneumonia, followed by bronchial surgery. Three patients manifested severe infection, and all patients improved and were discharged. Our results show that WUPyV persistently circulates in China. Further investigations on the clinical role and pathogenicity of WUPyV are necessary. Frontiers Media S.A. 2022-03-11 /pmc/articles/PMC8963484/ /pubmed/35360221 http://dx.doi.org/10.3389/fcimb.2021.835946 Text en Copyright © 2022 Zhao, Xu, Wang, Zhu, Wang, Liu, Ai, Feng, Deng, Sun, Li, Jin, Shang, Gao, Qian, Xu and Xie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Zhao, Hongwei
Xu, Wenmiao
Wang, Lijuan
Zhu, Yun
Wang, Xiaohui
Liu, Yingchao
Ai, Junhong
Feng, Qianyu
Deng, Li
Sun, Yun
Li, Changchong
Jin, Rong
Shang, Yunxiao
Gao, Hengmiao
Qian, Suyun
Xu, Lili
Xie, Zhengde
WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey
title WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey
title_full WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey
title_fullStr WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey
title_full_unstemmed WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey
title_short WU Polyomavirus Infection in Children With Acute Lower Respiratory Tract Infections in China, 2017 to 2019: Case Reports and Multicentre Epidemiological Survey
title_sort wu polyomavirus infection in children with acute lower respiratory tract infections in china, 2017 to 2019: case reports and multicentre epidemiological survey
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963484/
https://www.ncbi.nlm.nih.gov/pubmed/35360221
http://dx.doi.org/10.3389/fcimb.2021.835946
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