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Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods

Nonrandom selection in one-sample Mendelian Randomization (MR) results in biased estimates and inflated type I error rates only when the selection effects are sufficiently large. In two-sample MR, the different selection mechanisms in two samples may more seriously affect the causal effect estimatio...

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Detalles Bibliográficos
Autores principales:	Yu, Yuanyuan, Hou, Lei, Shi, Xu, Sun, Xiaoru, Liu, Xinhui, Yu, Yifan, Yuan, Zhongshang, Li, Hongkai, Xue, Fuzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963545/ https://www.ncbi.nlm.nih.gov/pubmed/35298462 http://dx.doi.org/10.1371/journal.pgen.1010107

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