Cargando…
Therapeutic potential of interferon-gamma in tuberculosis
Tuberculosis is one of the critical health problems worldwide. The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process. The interferon system, particularly the role of interf...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Association of Physical Chemists
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963577/ https://www.ncbi.nlm.nih.gov/pubmed/35360672 http://dx.doi.org/10.5599/admet.1078 |
_version_ | 1784678018771320832 |
---|---|
author | Berns, Svetlana A. Isakova, Julia A. Pekhtereva, Polina I. |
author_facet | Berns, Svetlana A. Isakova, Julia A. Pekhtereva, Polina I. |
author_sort | Berns, Svetlana A. |
collection | PubMed |
description | Tuberculosis is one of the critical health problems worldwide. The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process. The interferon system, particularly the role of interferon-gamma, has been identified as the main link in the immune response in tuberculosis. The clinical efficacy of interferon-gamma has been studied and evaluated in clinical trials since the end of the last century. There was obtained evidence of the clinical efficacy of interferon-gamma as part of complex therapy. Recent experimental data make it possible to consider interferon-gamma as a promising therapeutic option for the treatment of multidrug-resistant tuberculosis as part of complex therapy worthy of further studies. |
format | Online Article Text |
id | pubmed-8963577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | International Association of Physical Chemists |
record_format | MEDLINE/PubMed |
spelling | pubmed-89635772022-03-30 Therapeutic potential of interferon-gamma in tuberculosis Berns, Svetlana A. Isakova, Julia A. Pekhtereva, Polina I. ADMET DMPK Review Tuberculosis is one of the critical health problems worldwide. The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process. The interferon system, particularly the role of interferon-gamma, has been identified as the main link in the immune response in tuberculosis. The clinical efficacy of interferon-gamma has been studied and evaluated in clinical trials since the end of the last century. There was obtained evidence of the clinical efficacy of interferon-gamma as part of complex therapy. Recent experimental data make it possible to consider interferon-gamma as a promising therapeutic option for the treatment of multidrug-resistant tuberculosis as part of complex therapy worthy of further studies. International Association of Physical Chemists 2022-02-14 /pmc/articles/PMC8963577/ /pubmed/35360672 http://dx.doi.org/10.5599/admet.1078 Text en Copyright © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Berns, Svetlana A. Isakova, Julia A. Pekhtereva, Polina I. Therapeutic potential of interferon-gamma in tuberculosis |
title | Therapeutic potential of interferon-gamma in tuberculosis |
title_full | Therapeutic potential of interferon-gamma in tuberculosis |
title_fullStr | Therapeutic potential of interferon-gamma in tuberculosis |
title_full_unstemmed | Therapeutic potential of interferon-gamma in tuberculosis |
title_short | Therapeutic potential of interferon-gamma in tuberculosis |
title_sort | therapeutic potential of interferon-gamma in tuberculosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963577/ https://www.ncbi.nlm.nih.gov/pubmed/35360672 http://dx.doi.org/10.5599/admet.1078 |
work_keys_str_mv | AT bernssvetlanaa therapeuticpotentialofinterferongammaintuberculosis AT isakovajuliaa therapeuticpotentialofinterferongammaintuberculosis AT pekhterevapolinai therapeuticpotentialofinterferongammaintuberculosis |