Cargando…

Biophysical methods in early drug discovery

Biophysical methods such as mass spectrometry, surface plasmon resonance, nuclear magnetic resonance, and both differential scanning isothermal titration calorimetry are now well established as key components of the early drug discovery process. These approaches are used successfully for a range of...

Descripción completa

Detalles Bibliográficos
Autores principales: Holdgate, Geoffrey, Embrey, Kevin, Milbradt, Alexander, Davies, Gareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Association of Physical Chemists 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963580/
https://www.ncbi.nlm.nih.gov/pubmed/35359617
http://dx.doi.org/10.5599/admet.733
_version_ 1784678019523149824
author Holdgate, Geoffrey
Embrey, Kevin
Milbradt, Alexander
Davies, Gareth
author_facet Holdgate, Geoffrey
Embrey, Kevin
Milbradt, Alexander
Davies, Gareth
author_sort Holdgate, Geoffrey
collection PubMed
description Biophysical methods such as mass spectrometry, surface plasmon resonance, nuclear magnetic resonance, and both differential scanning isothermal titration calorimetry are now well established as key components of the early drug discovery process. These approaches are used successfully for a range of activities, including assay development, primary screening, hit confirmation and detailed mechanistic characterisation of compound binding. Matching the speed, sensitivity and information content of the various techniques to the generation of critical data and information required at each phase of the drug discovery process has been key. This review describes the framework by which these methods have been applied in the drug discovery process and provides case studies to exemplify the impact.
format Online
Article
Text
id pubmed-8963580
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher International Association of Physical Chemists
record_format MEDLINE/PubMed
spelling pubmed-89635802022-03-30 Biophysical methods in early drug discovery Holdgate, Geoffrey Embrey, Kevin Milbradt, Alexander Davies, Gareth ADMET DMPK Review Biophysical methods such as mass spectrometry, surface plasmon resonance, nuclear magnetic resonance, and both differential scanning isothermal titration calorimetry are now well established as key components of the early drug discovery process. These approaches are used successfully for a range of activities, including assay development, primary screening, hit confirmation and detailed mechanistic characterisation of compound binding. Matching the speed, sensitivity and information content of the various techniques to the generation of critical data and information required at each phase of the drug discovery process has been key. This review describes the framework by which these methods have been applied in the drug discovery process and provides case studies to exemplify the impact. International Association of Physical Chemists 2019-12-11 /pmc/articles/PMC8963580/ /pubmed/35359617 http://dx.doi.org/10.5599/admet.733 Text en Copyright © 2019 by the authors. https://creativecommons.org/licenses/by/4.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Holdgate, Geoffrey
Embrey, Kevin
Milbradt, Alexander
Davies, Gareth
Biophysical methods in early drug discovery
title Biophysical methods in early drug discovery
title_full Biophysical methods in early drug discovery
title_fullStr Biophysical methods in early drug discovery
title_full_unstemmed Biophysical methods in early drug discovery
title_short Biophysical methods in early drug discovery
title_sort biophysical methods in early drug discovery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963580/
https://www.ncbi.nlm.nih.gov/pubmed/35359617
http://dx.doi.org/10.5599/admet.733
work_keys_str_mv AT holdgategeoffrey biophysicalmethodsinearlydrugdiscovery
AT embreykevin biophysicalmethodsinearlydrugdiscovery
AT milbradtalexander biophysicalmethodsinearlydrugdiscovery
AT daviesgareth biophysicalmethodsinearlydrugdiscovery