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NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties
Determination of physico-chemical properties of compounds is one of the corner-stones in selection of hit molecules for further progression into lead development in the modern drug discovery process. The speed of traditional analyses and limited quantities of hit molecules are obstacles for efficien...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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International Association of Physical Chemists
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963582/ https://www.ncbi.nlm.nih.gov/pubmed/35359618 http://dx.doi.org/10.5599/admet.737 |
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author | Zloh, Mire |
author_facet | Zloh, Mire |
author_sort | Zloh, Mire |
collection | PubMed |
description | Determination of physico-chemical properties of compounds is one of the corner-stones in selection of hit molecules for further progression into lead development in the modern drug discovery process. The speed of traditional analyses and limited quantities of hit molecules are obstacles for efficient acquisition of experimental data. Herein, the range of applications of quantitative nuclear magnetic resonance (NMR) spectroscopy as a fast technique used to evaluate solubility, log P and pKa are discussed. |
format | Online Article Text |
id | pubmed-8963582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Association of Physical Chemists |
record_format | MEDLINE/PubMed |
spelling | pubmed-89635822022-03-30 NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties Zloh, Mire ADMET DMPK Review Determination of physico-chemical properties of compounds is one of the corner-stones in selection of hit molecules for further progression into lead development in the modern drug discovery process. The speed of traditional analyses and limited quantities of hit molecules are obstacles for efficient acquisition of experimental data. Herein, the range of applications of quantitative nuclear magnetic resonance (NMR) spectroscopy as a fast technique used to evaluate solubility, log P and pKa are discussed. International Association of Physical Chemists 2019-12-11 /pmc/articles/PMC8963582/ /pubmed/35359618 http://dx.doi.org/10.5599/admet.737 Text en Copyright © 2019 by the authors. https://creativecommons.org/licenses/by/4.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Zloh, Mire NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties |
title | NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties |
title_full | NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties |
title_fullStr | NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties |
title_full_unstemmed | NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties |
title_short | NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties |
title_sort | nmr spectroscopy in drug discovery and development: evaluation of physico-chemical properties |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963582/ https://www.ncbi.nlm.nih.gov/pubmed/35359618 http://dx.doi.org/10.5599/admet.737 |
work_keys_str_mv | AT zlohmire nmrspectroscopyindrugdiscoveryanddevelopmentevaluationofphysicochemicalproperties |